Differential gene expression associated with soybean oil level in the diet of pigs.

dc.contributorSIMARA LARISSA FANALLI, University of São Paulo
dc.contributorBRUNA PEREIRA MARTINS DA SILVA, University of São Paulo
dc.contributorJULIA DEZEN GOMES, University of São Paulo
dc.contributorVIVIAN VEZZONI DE ALMEIDA, Federal University of Goiás
dc.contributorFELIPE ANDRÉ OLIVEIRA FREITAS, University of São Paulo
dc.contributorGABRIEL COSTA MONTEIRO MOREIRA, University of Liège
dc.contributorBÁRBARA SILVA-VIGNATO, University of São Paulo
dc.contributorJULIANA AFONSO, University Federal of São Carlos
dc.contributorJAMES REECY, Iowa State University
dc.contributorJAMES KOLTES, Iowa State University
dc.contributorDAWN KOLTES, Iowa State University
dc.contributorLUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE
dc.contributorDORIAN JOHN GARRICK, Massey University
dc.contributorJÚLIO CESAR DE CARVALHO BALIEIRO, University of São Paulo
dc.contributorARIANA NASCIMENTO MEIRA, University of São Paulo
dc.contributorLUCIANA FREITAS, DB Genética de Suínos
dc.contributorLUIZ LEHMANN COUTINHO, University of São Paulo
dc.contributorHEIDGE FUKUMASU, University of São Paulo
dc.contributorGERSON BARRETO MOURÃO, University of São Paulo
dc.contributorSEVERINO MATIAS DE ALENCAR, University of São Paulo
dc.contributorALBINO LUCHIARI FILHO, University of São Paulo
dc.contributorALINE SILVA MELLO CESAR, University of São Paulo.
dc.creatorFINALLI, S. L.
dc.creatorSILVA, B. P. M. DA
dc.creatorGOMES, J. D.
dc.creatorALMEIDA, V. V. DE
dc.creatorFREITAS, F. A. O.
dc.creatorMOREIRA, G. C. M.
dc.creatorVIGNATO, B. S.
dc.creatorAFONSO, J.
dc.creatorREECY, J.
dc.creatorKOLTES, J.
dc.creatorKOLTES, D.
dc.creatorREGITANO, L. C. de A.
dc.creatorGARRICK, D. J.
dc.creatorBALIEIRO, J. C. DE C.
dc.creatorMEIRA, A. N.
dc.creatorFREITAS, L.
dc.creatorCOUTINHO, L. L.
dc.creatorFUKUMASU, H.
dc.creatorMOURÃO, G. B.
dc.creatorALENCAR, S. M. DE
dc.creatorLUCHIARI FILHO, A.
dc.creatorCESAR, A. S. M.
dc.date2022-09-01T17:22:23Z
dc.date2022-09-01T17:22:23Z
dc.date2022-09-01
dc.date2022
dc.date.accessioned2023-09-05T01:42:51Z
dc.date.available2023-09-05T01:42:51Z
dc.identifierAnimals, v. 12, n. 13 1632, jun. 2022.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1145998
dc.identifierhttps://doi.org/10.3390/ani12131632
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8632005
dc.descriptionThe aim of this study was to identify the differentially expressed genes (DEG) from the skeletal muscle and liver samples of animal models for metabolic diseases in humans. To perform the study, the fatty acid (FA) profile and RNA sequencing (RNA-Seq) data of 35 samples of liver tissue (SOY1.5, n = 17 and SOY3.0, n = 18) and 36 samples of skeletal muscle (SOY1.5, n = 18 and SOY3.0, n = 18) of Large White pigs were analyzed. The FA profile of the tissues was modified by the diet, mainly those related to monounsaturated (MUFA) and polyunsaturated (PUFA) FA. The skeletal muscle transcriptome analysis revealed 45 DEG (FDR 10%), and the functional enrichment analysis identified network maps related to inflammation, immune processes, and pathways associated with oxidative stress, type 2 diabetes, and metabolic dysfunction. For the liver tissue, the transcriptome profile analysis revealed 281 DEG, which participate in network maps related to neurodegenerative diseases. With this nutrigenomics study, we verified that different levels of soybean oil in the pig diet, an animal model for metabolic diseases in humans, affected the transcriptome profile of skeletal muscle and liver tissue. These findings may help to better understand the biological mechanisms that can be modulated by the diet.
dc.format21 p.
dc.languageIngles
dc.languageen
dc.rightsopenAccess
dc.subjectFatty acid
dc.subjectRNAseq
dc.subjectHepatic tissue
dc.subjectAnimal model
dc.subjectLongissimus lomborum
dc.subjectTranscriptome
dc.subjectImmune response
dc.subjectMetabolism
dc.titleDifferential gene expression associated with soybean oil level in the diet of pigs.
dc.typeArtigo de periódico


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