Comparative analyses of metabolic fingerprint integrated with cytotoxic activity and in silico approaches of the leaves extract of Spondias mombin L. and Spondias tuberosa Arr. Cam. from Northeast, Brazil.

dc.contributorJHONYSON ARRUDA CARVALHO GUEDES, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará; YURI GOMES SANTIAGO, Embrapa Agroindústria Tropical; LICIA DOS REIS LUZ, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará; Embrapa Agroindústria Tropical; MARIA FRANCILENE SOUZA SILVA, Núcleo de Pesquisa e Desenvolvimento de Medicamentos - NPDM, Universidade Federal do Ceará; CHRISTIANE MENDES CASSIMIRO RAMIRES, Empresa Paraibana de Pesquisa, Extensão Rural e Regularização Fundiária - EMPAER - PB; MARIA AUXILIADORA COELHO DE LIMA, CPATSA; VISELDO RIBEIRO DE OLIVEIRA, CPATSA; CLAUDIA DO Ó PESSOA, Núcleo de Pesquisa e Desenvolvimento de Medicamentos - NPDM, Universidade Federal do Ceará; KIRLEY MARQUES CANUTO, CNPAT; EDY SOUSA DE BRITO, CNPAT; MARCELO F. LIMA, Universidade Estadual Paulista (Unesp), Instituto de Biociências, Letras e Ciências Exatas (IBILCE), Câmpus São José do Rio Preto; RICARDO ELESBAO ALVES, CNAT; DAVILA ZAMPIERI, Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará; RONALDO FERREIRA DO NASCIMENTO, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará; GUILHERME JULIAO ZOCOLO, CNPAT.
dc.creatorGUEDES, J. A. C.
dc.creatorSANTIAGO, Y. G.
dc.creatorLUZ, L. dos R.
dc.creatorSILVA, M. F. S.
dc.creatorRAMIRES, C. M. C.
dc.creatorLIMA, M. A. C. de
dc.creatorOLIVEIRA, V. R. de
dc.creatorPESSOA. C. do Ó.
dc.creatorCANUTO, K. M.
dc.creatorBRITO, E. S. de
dc.creatorLIMA, M. F.
dc.creatorALVES, R. E.
dc.creatorZAMPIERI, D.
dc.creatorNASCIMENTO, R. F. do
dc.creatorZOCOLO, G. J.
dc.date2022-08-22T13:19:37Z
dc.date2022-08-22T13:19:37Z
dc.date2020-10-16
dc.date2020
dc.date.accessioned2023-09-05T01:38:50Z
dc.date.available2023-09-05T01:38:50Z
dc.identifierPhytochemistry Letters, v. 40, p. 26-36, 2020.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1125573
dc.identifierDOI: 10.1016/j.phytol.2020.09.003
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8631591
dc.descriptionSpondias species are a relevant source of natural-bioactive compounds in Brazilian folk medicine, and its biological potential has not been explored. Thus, this study aimed to determine the metabolomic fingerprint of Spondias mombin and Spondias tuberosa leaves based on the use of reversed-phase liquid chromatography coupled to a high-resolution mass spectrometer (UPLC-HRMS). The analysis by UPLC-HRMS allowed the annotation of 31 metabolites. The multivariate analysis allowed us to identify the biomarkers responsible for the distinction between species. Also, we correlate the biomarkers of S. mombin and S. tuberosa as supposed responsible for the difference in the degree of cytotoxicity between them. The in silico evaluation was performed to give more consistency to the correlation between biomarkers and cytotoxicity, which were compared to commercial drugs. Therefore, this study showed that S. mombin has the potential to become an input for the pharmaceutical industry as a source of raw material that can positively impact the sectors of agricultural production.
dc.languageIngles
dc.languageen
dc.rightsopenAccess
dc.subjectQuimiometria
dc.subjectHigh-resolution mass spectrometry
dc.subjectEspectrometria de massa de alta
dc.subjectCromatografia líquida
dc.subjectMetabolômica
dc.subjectPlanta nativa
dc.subjectUmbu
dc.subjectSpondias Mombin
dc.subjectAnacardiaceae
dc.subjectSpondias Tuberosa
dc.subjectCaatinga
dc.subjectChemometrics
dc.subjectLiquid chromatography
dc.subjectMetabolomics
dc.subjectYellow mombins
dc.subjectDialium guineense
dc.titleComparative analyses of metabolic fingerprint integrated with cytotoxic activity and in silico approaches of the leaves extract of Spondias mombin L. and Spondias tuberosa Arr. Cam. from Northeast, Brazil.
dc.typeArtigo de periódico


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