Effects of central imidazolinergic and alpha2-adrenergic activation on water intake

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSugawara, A. M.
dc.creatorMiguel, T. T.
dc.creatorPereira, D. T. B.
dc.creatorMenani, José Vanderlei
dc.creatorLuca Junior, Laurival Antonio de
dc.date2014-05-20T13:45:52Z
dc.date2014-05-20T13:45:52Z
dc.date2001-09-01
dc.date.accessioned2017-04-05T20:53:44Z
dc.date.available2017-04-05T20:53:44Z
dc.identifierBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 9, p. 1185-1190, 2001.
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/11449/16178
dc.identifier10.1590/S0100-879X2001000900012
dc.identifierS0100-879X2001000900012
dc.identifierS0100-879X2001000900012.pdf
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2001000900012
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/863050
dc.descriptionNon-adrenergic ligands that bind to imidazoline receptors (I-R), a selective ligand that binds to alpha2-adrenoceptors (alpha2-AR) and mixed ligands that bind to both receptors were tested for their action on water intake behavior of 24-h water-deprived rats. All drugs were injected into the third cerebral ventricle. Except for agmatine (80 nmol), mixed ligands binding to I-R/alpha2-AR such as guanabenz (40 nmol) and UK 14304 (20 nmol) inhibited water intake by 65% and up to 95%, respectively. The selective non-imidazoline alpha2-AR agonist, alpha-methylnoradrenaline, produced inhibition of water intake similar to that obtained with guanabenz, but at higher doses (80 nmol). The non-adrenergic I-R ligands histamine (160 nmol, mixed histaminergic and imidazoline ligand) and imidazole-4-acetic acid (80 nmol, imidazoline ligand) did not alter water intake. The results show that selective, non-imidazoline alpha2-AR activation suppresses water intake, and suggest that the action on imidazoline sites by non-adrenergic ligands is not sufficient to inhibit water intake.
dc.languageeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectimidazolines
dc.subjectagmatine
dc.subjectUK 14304
dc.subjectguanabenz
dc.subjectalpha-methylnoradrenaline
dc.subjectthirst
dc.subjectdehydration
dc.titleEffects of central imidazolinergic and alpha2-adrenergic activation on water intake
dc.typeOtro


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