Effect of electrolytic and chemical lesion by ibotenic acid of the septal area on water and salt intake

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSaad, W. A.
dc.creatorCamargo, LAD
dc.creatorAntunes-Rodrigues, J.
dc.creatorSimoes, S.
dc.date2014-05-20T13:45:41Z
dc.date2016-10-25T16:59:39Z
dc.date2014-05-20T13:45:41Z
dc.date2016-10-25T16:59:39Z
dc.date1998-09-15
dc.date.accessioned2017-04-05T20:53:10Z
dc.date.available2017-04-05T20:53:10Z
dc.identifierBrain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 47, n. 2, p. 163-169, 1998.
dc.identifier0361-9230
dc.identifierhttp://hdl.handle.net/11449/16083
dc.identifierhttp://acervodigital.unesp.br/handle/11449/16083
dc.identifier10.1016/S0361-9230(98)00057-4
dc.identifierWOS:000076762400008
dc.identifierhttp://dx.doi.org/10.1016/S0361-9230(98)00057-4
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/862978
dc.descriptionWater and sodium chloride intake was studied in male Holtzman rats weighing 250-300 g that had been subjected to electrolytic and chemical lesions of the septal area (SA). Water intake increased in animals with electrolytic lesion of the SA bilaterally from 169.37 +/- 8.55 (sham) to 214.87 +/- 23.10 ml/5 days (lesioned). Water intake decreased after ibotenic acid lesion of the SA from 229.33 +/- 27.60 to 127.33 +/- 22.84 ml/5 days. Sodium chloride intake (1.5%) increased in animals with electrolytic lesion of the SA from 10.0 +/- 1.73 to 15.5 +/- 1.95 ml/5 days after lesion. Also sodium chloride (1.5%) intake increased after ibotenic acid injection into the SA to a greater extent (from 7.83 +/- 1.25 to 14.33 +/- 1.87 ml/5 days). The results indicate that the water intake response may be due to lesions that involve cell bodies and fibers of passage and that the sodium intake response can also be induced by lesions which involve only cell bodies. Finally, these results led us to conclude that the SA uses its cell bodies and afferent bodies and fibers for processing inputs mediating water intake and salt appetite and that the cells bodies of the SA are implicated in increased water intake. (C) 1998 Elsevier B.V.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationBrain Research Bulletin
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectseptal area
dc.subjectwater and salt intake
dc.subjectelectrolytic lesion
dc.subjectibotenic acid lesion
dc.titleEffect of electrolytic and chemical lesion by ibotenic acid of the septal area on water and salt intake
dc.typeOtro


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