Involvement of forebrain imidazoline and alpha(2)-adrenergic receptors in the antidipsogenic response to moxonidine

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorAndrade, CAF
dc.creatorOliveira, L. B.
dc.creatorMartinez, G.
dc.creatorSilva, DCF
dc.creatorDe Luca, L. A.
dc.creatorMenani, José Vanderlei
dc.date2014-05-20T13:45:38Z
dc.date2014-05-20T13:45:38Z
dc.date2003-01-01
dc.date.accessioned2017-04-05T20:53:03Z
dc.date.available2017-04-05T20:53:03Z
dc.identifierAgmatine and Imidazolines: Their Novel Receptors and Enzymes. New York: New York Acad Sciences, v. 1009, p. 262-264, 2003.
dc.identifier0077-8923
dc.identifierhttp://hdl.handle.net/11449/16062
dc.identifier10.1196/annals.1304.032
dc.identifierWOS:000189443800032
dc.identifierhttp://dx.doi.org/10.1196/annals.1304.032
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/862960
dc.descriptionWe investigated the participation of central alpha(2)-adrenoceptors and imidazoline receptors in the inhibition of water deprivation-induced water intake in rats. The alpha(2)-adrenoceptor and imidazoline antagonist idazoxan (320 nmol), but not the alpha(2)-adrenoceptor antagonist yohimbine, abolished the antidipsogenic effect of moxonidine (alpha(2)-adrenoceptor and imidazoline agonist, 20 nmol) microinjected into the medial septal area. Yohimbine abolished the antidipsogenic effect of moxonidine intracerebroventricularly. Therefore, central moxonidine may inhibit water intake acting independently on both imidazoline receptors and alpha(2)-adrenoceptors at different forebrain sites.
dc.languageeng
dc.publisherNew York Acad Sciences
dc.relationAgmatine and Imidazolines: Their Novel Receptors and Enzymes
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectthirst
dc.subjectangiotensin II
dc.subjectdehydration
dc.subjectwater intake
dc.titleInvolvement of forebrain imidazoline and alpha(2)-adrenergic receptors in the antidipsogenic response to moxonidine
dc.typeOtro


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