Exercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesions

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorUniversidade de São Paulo (USP)
dc.creatorSerra, Andrey Jorge [UNIFESP]
dc.creatorHiguchi, Maria L.
dc.creatorIhara, Silvia Saiuli Miki [UNIFESP]
dc.creatorAntonio, Ednei Luiz [UNIFESP]
dc.creatorSantos, Marilia H. H.
dc.creatorBombig, Maria Teresa Nogueira [UNIFESP]
dc.creatorTucci, Paulo José Ferreira [UNIFESP]
dc.date.accessioned2016-01-24T13:51:23Z
dc.date.accessioned2023-09-04T19:22:10Z
dc.date.available2016-01-24T13:51:23Z
dc.date.available2023-09-04T19:22:10Z
dc.date.created2016-01-24T13:51:23Z
dc.date.issued2008-06-01
dc.identifierEuropean Journal of Heart Failure. Amsterdam: Elsevier B.V., v. 10, n. 6, p. 534-539, 2008.
dc.identifier1388-9842
dc.identifierhttp://repositorio.unifesp.br/handle/11600/30670
dc.identifier10.1016/j.ejheart.2008.03.016
dc.identifierWOS:000257618500003
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8625677
dc.description.abstractBackground: Sustained beta-adrenoreceptor activation promotes cardiac hypertrophy and cellular injury.Aims: To evaluate the cardioprotective effect of exercise on damage induced by beta-adrenergic hyperactivity.Methods: Male Wistar rats were randomised into four groups (n=8 per group): sedentary non-treated control (C), sedentary treated with isoproterenol 0.3 mg/kg/day administered subcutaneously for 8 days (1), exercised non-treated (E) and exercised plus isoproterenol administered during the last eight days of exercise (IE). Exercised animals ran on a treadmill for 1 h daily 6 times a week for 13 weeks.Results: Isoproterenol caused increases in left ventricle (LV) wet and dry weight/body weight ratio, LV water content and cardiomyocyte transverse diameter. Additionally, isoproterenol induced severe cellular lesions, necrosis, and apoptosis, increased collagen content and reduced capillary and fibre fractional areas. Notably, all of these abnormalities were completely prevented by exercise.Conclusion: Our data have demonstrated that complete cardioprotection is possible through exercise training; by preventing p-adrenergic hyperactivity-induced cardiac hypertrophy and structural injury. (c) 2008 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationEuropean Journal of Heart Failure
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.rightsAcesso aberto
dc.subjectmyocardial hypertrophy
dc.subjectisoproterenol
dc.subjectexercise training
dc.subjectcardioprotection
dc.titleExercise training prevents beta-adrenergic hyperactivity-induced myocardial hypertrophy and lesions
dc.typeArtigo


Este ítem pertenece a la siguiente institución