Long-term effect of carbodiimide on dentin matrix and resin-dentin bonds

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBedran-Russo, Ana Karina B.
dc.creatorVidal, Cristina M. P.
dc.creatorSantos, Paulo Henrique dos
dc.creatorCastellan, Carina S.
dc.date2013-09-30T18:29:58Z
dc.date2014-05-20T13:43:39Z
dc.date2016-10-25T16:58:11Z
dc.date2013-09-30T18:29:58Z
dc.date2014-05-20T13:43:39Z
dc.date2016-10-25T16:58:11Z
dc.date2010-07-01
dc.date.accessioned2017-04-05T20:47:34Z
dc.date.available2017-04-05T20:47:34Z
dc.identifierJournal of Biomedical Materials Research Part B-applied Biomaterials. Hoboken: Wiley-liss, v. 94B, n. 1, p. 250-255, 2010.
dc.identifier1552-4973
dc.identifierhttp://hdl.handle.net/11449/15248
dc.identifierhttp://acervodigital.unesp.br/handle/11449/15248
dc.identifier10.1002/jbm.b.31649
dc.identifierWOS:000278697400029
dc.identifierhttp://dx.doi.org/10.1002/jbm.b.31649
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/862283
dc.descriptionObjectives: To characterize the interaction of 1-Ethyl-3-[3-dimethylaminopropyl] carbodiimide Hydrochloride (EDC) with dentin matrix and its effect on the resin-dentin bond. Methods: Changes to the stiffness of demineralized dentin fragments treated with EDC/N-hydroxysuccinimide (NHS) in different solutions were evaluated at different time points. The resistance against enzymatic degradation was indirectly evaluated by ultimate tensile strength (UTS) test of demineralized dentin treated or not with EDC/NHS and subjected to collagenase digestion. Short- and long-term evaluations of the strength of resin-dentin interfaces treated with EDC/NHS for 1 h were performed using microtensile bond strength (mu TBS) test. All data (MPa) were individually analyzed using ANOVA and Tukey HSD tests (alpha = 0.05). Results: The different exposure times significantly increased the stiffness of dentin (p < 0.0001, control-5.15 and EDC/NHS-29.50), while no differences were observed among the different solutions of EDC/NHS (p = 0.063). Collagenase challenge did not affect the UTS values of EDC/NHS group (6.08) (p > 0.05), while complete degradation was observed for the control group (p = 0.0008, control-20.84 and EDC/NHS-43.15). EDC/NHS treatment did not significantly increase resin-dentin mu TBS, but the values remained stable after 12 months water storage (p < 0.05). Conclusions: Biomimetic use of EDC/NHS to induce exogenous collagen cross-links resulted in increased mechanical properties and stability of dentin matrix and dentin-resin interfaces. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 94B: 250-255, 2010.
dc.languageeng
dc.publisherWiley-liss
dc.relationJournal of Biomedical Materials Research Part B: Applied Biomaterials
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcollagen
dc.subjectdentin
dc.subjectcarbodiimide
dc.subjectbiomimetic
dc.subjectmechanical properties
dc.subjectdegradation
dc.titleLong-term effect of carbodiimide on dentin matrix and resin-dentin bonds
dc.typeOtro


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