Epigenetic mechanisms in gastric cancer

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorFed Univ Para
dc.creatorGigek, Carolina Oliveira [UNIFESP]
dc.creatorChen, Elizabeth Suchi [UNIFESP]
dc.creatorCalcagno, Danielle Queiroz [UNIFESP]
dc.creatorWisnieski, Fernanda [UNIFESP]
dc.creatorBurbano, Rommel Rodriguez
dc.creatorCardoso Smith, Marilia Arruda [UNIFESP]
dc.date.accessioned2016-01-24T14:27:21Z
dc.date.accessioned2023-09-04T19:06:31Z
dc.date.available2016-01-24T14:27:21Z
dc.date.available2023-09-04T19:06:31Z
dc.date.created2016-01-24T14:27:21Z
dc.date.issued2012-06-01
dc.identifierEpigenomics. London: Future Medicine Ltd, v. 4, n. 3, p. 279-294, 2012.
dc.identifier1750-1911
dc.identifierhttp://repositorio.unifesp.br/handle/11600/34984
dc.identifier10.2217/EPI.12.22
dc.identifierWOS:000306530200007
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8622819
dc.description.abstractCancer is considered one of the major health issues worldwide, and gastric cancer accounted for 8% of total cases and 10% of total deaths in 2008. Gastric cancer is considered an age-related disease, and the total number of newly diagnosed cases has been increasing as a result of the higher life expectancy. Therefore, the basic mechanisms underlying gastric tumorigenesis is worth investigation. This review provides an overview of the epigenetic mechanisms, such as DNA methylation, histone modifications, chromatin remodeling complex and miRNA, involved in gastric cancer. As the studies in gastric cancer continue, the mapping of an epigenome code is not far for this disease. in conclusion, an epigenetic therapy might appear in the not too distant future.
dc.languageeng
dc.publisherFuture Medicine Ltd
dc.relationEpigenomics
dc.rightsAcesso restrito
dc.subjectchromatin remodeling complex
dc.subjectDNA methylation
dc.subjectepigenetics
dc.subjectgastric cancer
dc.subjecthistone acetylation
dc.subjecthistone methylation
dc.subjecthypermethylation
dc.subjectmiRNA
dc.subjectphosphorylation
dc.titleEpigenetic mechanisms in gastric cancer
dc.typeResenha


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