Effect of platelet-rich plasma on bone healing of autogenous bone grafts in critical-size defects

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorNagata, Maria José Hitomi
dc.creatorMelo, Luiz. G. N.
dc.creatorMessora, Michel R.
dc.creatorBomfim, Suely Regina Mogami
dc.creatorFucini, Stephen E.
dc.creatorGarcia, Valdir Gouveia
dc.creatorBosco, Álvaro Francisco
dc.creatorOkamoto, Tetuo
dc.date2013-09-30T18:29:24Z
dc.date2014-05-20T13:43:15Z
dc.date2016-10-25T16:57:51Z
dc.date2013-09-30T18:29:24Z
dc.date2014-05-20T13:43:15Z
dc.date2016-10-25T16:57:51Z
dc.date2009-09-01
dc.date.accessioned2017-04-05T20:46:24Z
dc.date.available2017-04-05T20:46:24Z
dc.identifierJournal of Clinical Periodontology. Malden: Wiley-blackwell Publishing, Inc, v. 36, n. 9, p. 775-783, 2009.
dc.identifier0303-6979
dc.identifierhttp://hdl.handle.net/11449/15064
dc.identifierhttp://acervodigital.unesp.br/handle/11449/15064
dc.identifier10.1111/j.1600-051X.2009.01450.x
dc.identifierWOS:000268924600008
dc.identifierhttp://dx.doi.org/10.1111/j.1600-051X.2009.01450.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/862129
dc.descriptionAimThis study histologically analysed the effect of autogenous platelet-rich plasma (PRP), prepared according to a new semiautomatic system, on healing of autogenous bone (AB) grafts placed in surgically created critical-size defects (CSD) in rabbit calvaria.Material and MethodsSixty rabbits were divided into three groups: C, AB and AB/PRP. A CSD was created in the calvarium of each animal. In Group C (control), the defect was filled by blood clot only. In Group AB (autogenous bone graft), the defect was filled with particulate autogenous bone. In Group AB/PRP (autogenous bone graft with platelet-rich plasma), it was filled with particulate autogenous bone combined with PRP. All groups were divided into subgroups (n=10) and euthanized at 4 or 12 weeks post-operatively. Histometric and histologic analyses were performed. Data were statistically analysed (anova, t-test, p < 0.05).ResultsGroup C presented significantly less bone formation compared with Group AB and AB/PRP in both periods of analysis (p < 0.001). At 4 weeks, Group AB/PRP showed a statistically greater amount of bone formation than Group AB (64.44 +/- 15.0% versus 46.88 +/- 14.15%; p=0.0181). At 12 weeks, no statistically significant differences were observed between Groups AB and AB/PRP (75.0 +/- 8.11% versus 77.90 +/- 8.13%; p > 0.05). It is notable that the amount of new bone formation in Group AB/PRP at 4 weeks was similar to that of Group AB at 12 weeks (p > 0.05).ConclusionWithin its limitation, the present study has indicated that (i) AB and AB/PRP significantly improved bone formation and (ii) a beneficial effect of PRP was limited to an initial healing period of 4 weeks.
dc.languageeng
dc.publisherWiley-Blackwell Publishing, Inc
dc.relationJournal of Clinical Periodontology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbone grafting
dc.subjectbone regeneration
dc.subjectgrowth factors
dc.subjectin vivo model
dc.subjectplatelets
dc.titleEffect of platelet-rich plasma on bone healing of autogenous bone grafts in critical-size defects
dc.typeOtro


Este ítem pertenece a la siguiente institución