Alterations in Calcium Signaling and a Decrease in Bcl-2 Expression: Possible Correlation With Apoptosis in Aged Striatum

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorButantan Inst
dc.contributorMed Univ S Carolina
dc.creatorUreshino, Rodrigo Portes [UNIFESP]
dc.creatorBertoncini, Clelia Rejane Antonio [UNIFESP]
dc.creatorFernandes, Maria Jose da Silva [UNIFESP]
dc.creatorAbdalla, Fernando Mauricio Francis
dc.creatorPorto, Catarina Segreti [UNIFESP]
dc.creatorHsu, Yi-Te
dc.creatorLopes, Guiomar Silva [UNIFESP]
dc.creatorSmaili, Soraya Soubhi [UNIFESP]
dc.date.accessioned2016-01-24T13:59:14Z
dc.date.accessioned2023-09-04T18:55:10Z
dc.date.available2016-01-24T13:59:14Z
dc.date.available2023-09-04T18:55:10Z
dc.date.created2016-01-24T13:59:14Z
dc.date.issued2010-02-01
dc.identifierJournal of Neuroscience Research. Hoboken: Wiley-liss, v. 88, n. 2, p. 438-447, 2010.
dc.identifier0360-4012
dc.identifierhttps://repositorio.unifesp.br/handle/11600/32204
dc.identifier10.1002/jnr.22214
dc.identifierWOS:000273361600021
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8620590
dc.description.abstractAging is a multifaceted process associated with various functional and structural deficits that might be evolved in degenerative diseases. It has been shown that neurodegenerative disorders are associated with alterations in Ca(2+) homeostasis. Thus, in the present work, we have investigated Ca(2+) signaling and apoptosis in aged striatum. Our results show that glutamate and NMDA evoke a greater Ca(2+) rise in striatum slices from aged animals. However, this difference is not present when glutamate is tested in the absence of external Ca(2+). Immunostaining of glutamate receptors shows that only NMDA receptors (NRI) are increased in the striatum of aged rats. Increases in mitochondrial Ca(2+) content and in the reactive oxygen species levels were also observed in aged animals, which could be associated with tissue vulnerability. in addition, a decrease in the Bcl-2 protein expression and an enhancement in apoptosis were also present in aged striatum. Together the results indicate that, in aged animals, alterations in Ca(2+) handling coupled to an increase in ROS accumulation and a decrease in the prosurvival protein Bcl-2 may contribute to apoptosis induction and cell death in rat striatum. (C) 2009 Wiley-Liss, Inc.
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationJournal of Neuroscience Research
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.rightsAcesso restrito
dc.subjectAging
dc.subjectStriatum
dc.subjectGlutamate
dc.subjectCalcium
dc.subjectApoptosis
dc.subjectBcl-2
dc.titleAlterations in Calcium Signaling and a Decrease in Bcl-2 Expression: Possible Correlation With Apoptosis in Aged Striatum
dc.typeArtigo


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