NaF treatment increases TNF-alpha and resistin concentrations and reduces insulin signal in rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorChiba, Fernando Yamamoto
dc.creatorColombo, Natalia Helena
dc.creatorShirakashi, Daisy Jaqueline
dc.creatorda Silva, Viviane Clicie
dc.creatorMoimaz, Suzely Adas Saliba
dc.creatorGarbin, Clea Adas Saliba
dc.creatorSilva, Cristina Antoniali
dc.creatorSumida, Doris Hissako
dc.date2013-09-30T18:29:11Z
dc.date2014-05-20T13:43:01Z
dc.date2016-10-25T16:57:41Z
dc.date2013-09-30T18:29:11Z
dc.date2014-05-20T13:43:01Z
dc.date2016-10-25T16:57:41Z
dc.date2012-04-01
dc.date.accessioned2017-04-05T20:45:46Z
dc.date.available2017-04-05T20:45:46Z
dc.identifierJournal of Fluorine Chemistry. Lausanne: Elsevier B.V. Sa, v. 136, p. 3-7, 2012.
dc.identifier0022-1139
dc.identifierhttp://hdl.handle.net/11449/14969
dc.identifierhttp://acervodigital.unesp.br/handle/11449/14969
dc.identifier10.1016/j.jfluchem.2011.12.006
dc.identifierWOS:000302976900001
dc.identifierhttp://dx.doi.org/10.1016/j.jfluchem.2011.12.006
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/862044
dc.descriptionThe use of fluoridated products has significantly contributed to the reduction in rates of dental caries. However, excessive sodium fluoride (NaF) intake promotes inhibition of glycolysis, decrease in insulin secretion, hyperglycemia, and insulin resistance. Seven-week-old castrated male Wistar rats were used to evaluate the chronic effect of NaF on insulin sensitivity, insulin signal transduction in white adipose tissue (WAT), and plasma TNF-alpha and resistin concentrations. The animals were randomly divided into two groups: (1) control group (CN); (2) fluoride (F) group, which was treated with NaF in the drinking water and F in the food pellets (estimated total F intake: 4.0 mg/kg bw/day). After 42 days, an intravenous insulin tolerance test (0.75 U/kg), plasma TNF-alpha and resistin quantification analysis, and insulin receptor substrate (pp185 - IRS-1/IRS-2) tyrosine phosphorylation and IRS-1 serine phosphorylation status tests in WAT were performed. The chronic treatment with F promoted: (1) decrease in pp185 (IRS-1/IRS-2) tyrosine phosphorylation status in the WAT; (2) increase in IRS-1 serine phosphorylation status in the WAT; (3) increase in plasma concentrations of TNF-alpha and resistin; and (4) decrease in insulin sensitivity. (C) 2011 Elsevier B.V. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherElsevier B.V. Sa
dc.relationJournal of Fluorine Chemistry
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFluorine
dc.subjectInsulin receptor substrate proteins
dc.subjectDiabetes mellitus
dc.subjectInsulin resistance
dc.subjectFluorides
dc.titleNaF treatment increases TNF-alpha and resistin concentrations and reduces insulin signal in rats
dc.typeOtro


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