Otro
Action of nicotine and ovariectomy on bone regeneration after tooth extraction in rats
Registro en:
Journal of Oral and Maxillofacial Surgery. Philadelphia: W B Saunders Co-elsevier Inc, v. 68, n. 11, p. 2675-2681, 2010.
0278-2391
10.1016/j.joms.2010.04.018
WOS:000283971400006
Autor
Ribeiro Machado, Giscard Jose
Damasio Dias, Sheila Monica
Bosco, Álvaro Francisco
Okamoto, Tetuo
Bedran de Castro, Joao Cesar
Dornelles, Rita Cassia Menegati
Resumen
Purpose: The purpose of this study was to evaluate the effects of nicotine and ovariectomy on alveolar bone regeneration after exodontias in rats.Materials and Methods: For 30 days, sham ovariectomized (OVX)/NaCl, sham OVX/nicotine, OVX/NaCl, and OVX/nicotine animals were given 2 daily injections of saline or hemisulfate of nicotine. After this period, exodontic procedures were carried out and treatment continued up to the time of euthanasia on clays 7 and 14 when the alveoli were removed for further analyses.Results: The data confirmed that nicotine significantly delays the alveolar regeneration process after dental extraction in rats and showed that the association of nicotine with ovariectomy exacerbates these results.Conclusion: These results indicate that nicotine potentiated the effect of estrogen deficiency on bone regeneration induced by ovariectomy. (c) 2010 American Association of Oral and Maxillofacial Surgeons Oral Maxillofac Surg 68:2675-2681, 2010