dc.contributor | http://lattes.cnpq.br/5559309395232147 | |
dc.creator | Maes, Michael | |
dc.creator | Nani, João Victor [UNIFESP] | |
dc.creator | Noto, Cristiano [UNIFESP] | |
dc.creator | Rizzo, Lucas | |
dc.creator | Hayashi, Mirian A. F. [UNIFESP] | |
dc.creator | Brietzke, Elisa | |
dc.date.accessioned | 2021-10-29T17:13:07Z | |
dc.date.accessioned | 2023-09-04T18:42:11Z | |
dc.date.available | 2021-10-29T17:13:07Z | |
dc.date.available | 2023-09-04T18:42:11Z | |
dc.date.created | 2021-10-29T17:13:07Z | |
dc.date.issued | 2020-09-11 | |
dc.identifier | Molecular Neurobiology, Clifton, NJ, v. 58, n. 1, p. 229-242, Jan. 2021 | |
dc.identifier | 1559-1182 | |
dc.identifier | https://repositorio.unifesp.br/xmlui/handle/11600/62166 | |
dc.identifier | 10.1007/s12035-020-02110-1 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8617995 | |
dc.description.abstract | There is now evidence that, based on cytokine profiles, bipolar disorder (BD) is accompanied by simultaneous activation of the immune-inflammatory response system (IRS) and the compensatory immune-regulatory system (CIRS), and that both components may be associated with the staging of illness. Nevertheless, no BD studies have evaluated the IRS/CIRS ratio using CD (cluster of differentiation) molecules expressed by peripheral blood activated T effector (Teff) and T regulatory (Treg) subpopulations. This study examined Teff/Treg subsets both before and after ex vivo anti-CD3/CD28 stimulation using flow cytometric immunophenotyping in 25 symptomatic remitted BD patients and 21 healthy controls and assessed human cytomegalovirus (HCMV)-specific IgG antibodies. BD is associated with a significantly lowered frequency of unstimulated CD3 + CD8 + CD71+ and CD4 + CD25 + FOXP3 and increased CD4 + CD25 + FOXP3 + CD152+ frequencies and with lowered stimulated frequencies of CD3 + CD8 + CD71+, CD4 + CD25 + FOXP3 + CD152+, and CD4 + CD25 + FOXP3 + GARP cells and, consequently, by an increased stimulated Teff/Treg ratio. Moreover, the number of manic, but not hypomanic or depressive episodes, is significantly and negatively associated with the stimulated proportions of CD3 + CD4 + CD154+, and CD69+ and CD71+ expression on CD4+ and CD8+ cells, while duration of illness (≥ 10 years) is accompanied by a depleted frequency of stimulated CD152+ Treg, and CD154+ and CD71+ CD4+ T cells. BD and anti-human cytomegalovirus (HCMV) IgG levels significantly interact to decrease the expression of CD4 + CD25 + FOXP+GARP T phenotypes. In conclusion, in BD patients, immune injuries, staging, and HCMV seropositivity interact and cause CIRS dysfunctions and exaggerated IRS responses, which play a key role in parainflammation and neuroaffective toxicity. HCMV seropositivity contributes to an immune-risk phenotype in BD. | |
dc.publisher | Humana Press | |
dc.relation | Molecular Neurobiology | |
dc.rights | Acesso aberto | |
dc.subject | Bipolar depression | |
dc.subject | Cytokines | |
dc.subject | Inflammation | |
dc.subject | Neuroimmunomodulation | |
dc.subject | Psychoneuroimmunology | |
dc.subject | Staging | |
dc.title | Impairments in peripheral blood T effector and T regulatory lymphocytes in bipolar disorder are associated with staging of illness and anti-cytomegalovirus IgG levels | |
dc.type | Artigo | |