Effects of Zolpidem CR on Sleep and Nocturnal Ventilation in Patients with Heart Failure

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorGatti, Rodrigo Castiglia [UNIFESP]
dc.creatorBurke, Patrick Rademaker [UNIFESP]
dc.creatorOtuyama, Leonardo Jun [UNIFESP]
dc.creatorAlmeida, Dirceu Rodrigues de [UNIFESP]
dc.creatorTufik, Sergio [UNIFESP]
dc.creatorPoyares, Dalva [UNIFESP]
dc.date.accessioned2020-08-14T13:44:01Z
dc.date.accessioned2023-09-04T18:39:15Z
dc.date.available2020-08-14T13:44:01Z
dc.date.available2023-09-04T18:39:15Z
dc.date.created2020-08-14T13:44:01Z
dc.date.issued2016
dc.identifierSleep. Westchester, v. 39, n. 8, p. 1501-1505, 2016.
dc.identifier0161-8105
dc.identifierhttps://repositorio.unifesp.br/handle/11600/57488
dc.identifierWOS000381746800004.pdf
dc.identifier10.5665/sleep.6006
dc.identifierWOS:000381746800004
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8617354
dc.description.abstractStudy Objective: This study aimed to evaluate the effects of zolpidem CR (controlled release) on sleep and nocturnal ventilation in patients with congestive heart failure, a population at risk for insomnia and poor sleep quality. Methods: Fifteen patients with heart failure (ischemic cardiomyopathy) and ejection fraction ≤ 45% in NYHA functional class I or II were evaluated with full polysomnography in a placebo-controlled, double-blind, randomized trial. Patients underwent three tests: (1) baseline polysomnography and, after randomization, (2) a new test with zolpidem CR 12.5 mg or placebo, and after 1 week, (3) a new polysomnography, crossing the “medication” used. Results: A 16% increase in total sleep time was found with the use of zolpidem CR and an increase in stage 3 NREM sleep (slow wave sleep). The apnea hypopnea index (AHI) did not change with zolpidem CR even after controlling for supine position; however, a slight but significant decrease was observed in lowest oxygen saturation compared with baseline and placebo conditions (83.60 ± 5.51; 84.43 ± 3.80; 80.71 ± 5.18, P = 0.002). Conclusion: Zolpidem CR improved sleep structure in patients with heart failure, did not change apnea hypopnea index, but slightly decreased lowest oxygen saturation.
dc.languageeng
dc.publisherAmer Acad Sleep Medicine
dc.relationSleep
dc.rightsAcesso aberto
dc.subjectHeart failure
dc.subjectPolysomnography
dc.subjectZolpidem CR
dc.subjectSleep
dc.titleEffects of Zolpidem CR on Sleep and Nocturnal Ventilation in Patients with Heart Failure
dc.typeArtigo


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