Dimethyl sulfoxide as a block to the deleterious effect of nicotine in a random skin flap in the rat

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorLeite, Mauro Toledo [UNIFESP]
dc.creatorGomes, Heitor Carvalho [UNIFESP]
dc.creatorPercario, Sandro [UNIFESP]
dc.creatorAbrantes, Claudia Regina [UNIFESP]
dc.creatorFerreira, Lydia Masako [UNIFESP]
dc.date.accessioned2016-01-24T13:49:16Z
dc.date.accessioned2023-09-04T18:30:36Z
dc.date.available2016-01-24T13:49:16Z
dc.date.available2023-09-04T18:30:36Z
dc.date.created2016-01-24T13:49:16Z
dc.date.issued2007-12-01
dc.identifierPlastic and Reconstructive Surgery. Philadelphia: Lippincott Williams & Wilkins, v. 120, n. 7, p. 1819-1822, 2007.
dc.identifier0032-1052
dc.identifierhttp://repositorio.unifesp.br/handle/11600/30198
dc.identifier10.1097/01.prs.0000287134.60766.23
dc.identifierWOS:000251668400008
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8615533
dc.description.abstractBackground: in plastic surgery, a causal relationship between heavy smoking and flap necrosis has been shown. the deleterious effect of nicotine in random skin flaps in rats has also been proven, being related to vasoconstriction and possibly reactive oxygen species. This study aimed to verify the capacity of dimethyl sulfoxide, an antioxidant, to block the deleterious effect of nicotine in a random skin flap.Methods: Fourteen adult male Wistar-EPM rats were distributed at random into two groups of seven animals. the nicotine group received this drug subcutaneously (1.2 mg/kg/day), for I week before flap elevation. the nicotine plus dimethyl sulfoxide group followed the same routine. Five minutes before the surgical procedure, rats in the nicotine group received distilled water orally and rats in the nicotine plus dimethyl sulfoxide group received dimethyl sulfoxide orally (2 ml/kg). Blood and skin tissue samples were collected to allow determination of malondialdehyde levels.Results: the nicotine group had a mean value of 40.2 percent and the nicotine plus dimethyl sulfoxide group had a mean value of 20.6 percent necrosis (p = 0.009). Malondialdehyde levels in both serum and skin samples were lower in the animals that received dimethyl sulfoxide.Conclusion: the deleterious effect of nicotine was effectively blocked by dimethyl sulfoxide.
dc.languageeng
dc.publisherLippincott Williams & Wilkins
dc.relationPlastic and Reconstructive Surgery
dc.rightsAcesso restrito
dc.titleDimethyl sulfoxide as a block to the deleterious effect of nicotine in a random skin flap in the rat
dc.typeArtigo


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