dc.contributor | Universidade Federal de São Paulo (UNIFESP) | |
dc.creator | Anna, Ana Estela B. P. P. Sant' [UNIFESP] | |
dc.creator | Hazarbassanov, Rossen M. [UNIFESP] | |
dc.creator | Freitas, Denise de [UNIFESP] | |
dc.creator | Gomes, José Álvaro Pereira [UNIFESP] | |
dc.date.accessioned | 2016-01-24T14:17:54Z | |
dc.date.accessioned | 2023-09-04T18:24:23Z | |
dc.date.available | 2016-01-24T14:17:54Z | |
dc.date.available | 2023-09-04T18:24:23Z | |
dc.date.created | 2016-01-24T14:17:54Z | |
dc.date.issued | 2012-02-01 | |
dc.identifier | British Journal of Ophthalmology. London: B M J Publishing Group, v. 96, n. 2, p. 234-239, 2012. | |
dc.identifier | 0007-1161 | |
dc.identifier | http://repositorio.unifesp.br/handle/11600/34611 | |
dc.identifier | 10.1136/bjo.2010.199901 | |
dc.identifier | WOS:000299318700017 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8614226 | |
dc.description.abstract | Objective To evaluate minor salivary glands and labial mucous membrane graft in patients with severe symblepharon and dry eye secondary to Stevens-Johnson syndrome (SJS).Methods A prospective, non-comparative, interventional case series of 19 patients with severe symblepharon and dry eye secondary to SJS who underwent labial mucous membrane and minor salivary glands transplantation. A complete ophthalmic examination including the Schirmer I test was performed prior to and following surgery. All patients had a preoperative Schirmer I test value of zero.Results Nineteen patients with severe symblepharon and dry eye secondary to SJS were included in the study. There was a statistically significant improvement in the best spectacle-corrected visual acuity in eight patients (t test; p = 0.0070). Values obtained in the Schirmer I test improved significantly in 14 eyes (73.7%) 6 months following surgery (chi(2) test; p = 0.0094). A statistically significant increase in tear production (Schirmer I test) was found in eyes that received more than 10 glands per graft compared with eyes that received fewer glands (chi(2) test; p = 0.0096). Corneal transparency improved significantly in 11 (72.2%) eyes and corneal neovascularisation improved significantly in five eyes (29.4%) (McNemar test; p = 0.001 and p = 0.0005). the symptoms questionnaire revealed improvement in foreign body sensation in 53.6% of the patients, in photophobia in 50.2% and in pain in 54.8% (Kruskal-Wallis test; p = 0.0167).Conclusion Labial mucous membrane and minor salivary glands transplantation were found to constitute a good option for the treatment of severe symblepharon and dry eye secondary to SJS. This may be considered as a step prior to limbal stem cell and corneal transplantation in these patients. | |
dc.language | eng | |
dc.publisher | B M J Publishing Group | |
dc.relation | British Journal of Ophthalmology | |
dc.rights | Acesso restrito | |
dc.title | Minor salivary glands and labial mucous membrane graft in the treatment of severe symblepharon and dry eye in patients with Stevens-Johnson syndrome | |
dc.type | Artigo | |