The pilocarpine model of epilepsy in mice

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorCavalheiro, E. A.
dc.creatorSantos, N. F.
dc.creatorPriel, M. R.
dc.date.accessioned2016-01-24T11:40:35Z
dc.date.accessioned2023-09-04T18:20:42Z
dc.date.available2016-01-24T11:40:35Z
dc.date.available2023-09-04T18:20:42Z
dc.date.created2016-01-24T11:40:35Z
dc.date.issued1996-10-01
dc.identifierEpilepsia. Malden: Wiley-Blackwell, v. 37, n. 10, p. 1015-1019, 1996.
dc.identifier0013-9580
dc.identifierhttp://repositorio.unifesp.br/handle/11600/25633
dc.identifier10.1111/j.1528-1157.1996.tb00541.x
dc.identifierWOS:A1996VH59100016
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8613439
dc.description.abstractPurpose: To characterize the acute and chronic behavioral, electrographic and histologic effects of sustained seizures induced by pilocarpine in mice.Methods: After status epilepticus, the surviving animals were continuously monitored for 24 h/day for less than or equal to 120 days. the brains were processed by using neo-Timm and Nissl stains.Results: the first spontaneous seizures occurred between 4 and 42 days after status epilepticus. the mean ''seizure-silent period'' lasted for 14.4 +/- 11.9 days. During the chronic phase, recurrent spontaneous seizures were observed 1-5 times per animal per week and were associated with sprouting in the supragranular layer of the dentate gyrus.Conclusions: Structural brain damage promoted by pilocarpine-induced status epilepticus may underlie or be associated with recurrent spontaneous seizures in mice.
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationEpilepsia
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.rightsAcesso restrito
dc.subjecttemporal lobe epilepsy
dc.subjectmossy fiber sprouting
dc.subjectrecurrent spontaneous seizures
dc.subjectchronic epilepsy
dc.subjectmice
dc.titleThe pilocarpine model of epilepsy in mice
dc.typeArtigo


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