Antinociceptive and Antiinflammatory Activities of Grandisin extracted from Virola surinamensis

dc.contributorUniversidade Federal de Goiás (UFG)
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorCarvalho, Adryano A. V.
dc.creatorGaldino, Pablinny M.
dc.creatorNascimento, Marcus V. M.
dc.creatorKato, Massuo Jorge
dc.creatorValadares, Marize C.
dc.creatorCunha, Luiz C.
dc.creatorCosta, Elson Alves [UNIFESP]
dc.date.accessioned2016-01-24T13:59:04Z
dc.date.accessioned2023-09-04T18:20:31Z
dc.date.available2016-01-24T13:59:04Z
dc.date.available2023-09-04T18:20:31Z
dc.date.created2016-01-24T13:59:04Z
dc.date.issued2010-01-01
dc.identifierPhytotherapy Research. Chichester: John Wiley & Sons Ltd, v. 24, n. 1, p. 113-118, 2010.
dc.identifier0951-418X
dc.identifierhttp://repositorio.unifesp.br/handle/11600/32073
dc.identifier10.1002/ptr.2882
dc.identifierWOS:000273691400020
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8613400
dc.description.abstractThe antinociceptive and antiinflammatory properties of the neolignan, grandisin, isolated from Virola surinamensis (Myristicaceae) were investigated. Grandisin (GRA) is present in several plant species from Brazil used in popular medicine for the treatment of disorders such as colic, inflammation, rheumatism, dyspepsia and liver dysfunction. These studies demonstrated that GRA is able to inhibit the acetic acid-induced writhing in mice dose-dependently, and that this effect is not caused by motor incoordination or sedation due to depressant effect in the CNS. Through the formalin test the anti inflammatory activity of GRA was characterized, this substance reduced the time licking the paw by 60.5% (only in the second phase (inflammatory pain). This activity was also verified by the oil-induced ear oedema test, where GRA 10.0 mg/kg reduced the oedema by 36.4%. the results suggest that GRA has antinociceptive effects arising from antiinflammatory activity. Copyright (C) 2009 John Wiley & Sons, Ltd.
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationPhytotherapy Research
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.rightsAcesso restrito
dc.subjectantinociceptive and antiinflammatory activity
dc.subjectgrandisin
dc.subjectVirola surinamensis
dc.titleAntinociceptive and Antiinflammatory Activities of Grandisin extracted from Virola surinamensis
dc.typeArtigo


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