Constituents and antiulcer effect of Alchornea glandulosa: Activation of cell proliferation in gastric mucosa during the healing process

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCalvo, Tamara Regina
dc.creatorLima, Zeila Pinheiro
dc.creatorSilva, Janaina Scaramelo
dc.creatorRodrigues Ballesteros, Katia Veronica
dc.creatorPellizzon, Claudia Helena
dc.creatorHiruma-Lima, Clelia Akiko
dc.creatorTamashiro, Jorge
dc.creatorSouza Brito, Alba Regina Monteiro
dc.creatorTakahira, Regina Kiomi
dc.creatorVilegas, Wagner
dc.date2014-05-20T13:39:20Z
dc.date2014-05-20T13:39:20Z
dc.date2007-03-01
dc.date.accessioned2017-04-05T20:37:05Z
dc.date.available2017-04-05T20:37:05Z
dc.identifierBiological & Pharmaceutical Bulletin. Tokyo: Pharmaceutical Soc Japan, v. 30, n. 3, p. 451-459, 2007.
dc.identifier0918-6158
dc.identifierhttp://hdl.handle.net/11449/13647
dc.identifier10.1248/bpb.30.451
dc.identifierWOS:000245938200010
dc.identifierWOS000245938200010.pdf
dc.identifier0000-0003-3323-4199
dc.identifier0000-0002-8645-3777
dc.identifier0000-0003-3032-2556
dc.identifierhttp://dx.doi.org/10.1248/bpb.30.451
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/860917
dc.descriptionAlchornea glandulosa (Euphorbiaceae) is a plant used in folk medicine as an antiulcer agent. Rats pretreated with methanolic extract obtained from the leaves of A. glandulosa (AG) showed a dose-dependent effect and significant reduction of gastric ulcers induced by absolute ethanol at the doses of 500 (57%) and 1000 mg/kg (35%) in relation to the control group. Pretreatment of mice with AG (500, 1000 mg/kg, p.o.) showed dose-dependent activity and significantly decreased the severity of lesions caused by HCl/ethanol and by non steroidal anti inflammatory drug-induced gastric lesions. Pretreatment with AG also induced antisecretory action via local and systemic routes and a significant decrease in the total gastric acid content. The gastroprotective effects of AG involved the participation of nitric oxide and increased levels of endogenous sulfhydryl compounds, which are defensive mechanisms of the gastrointestinal mucosa against aggressive factors. The ability of AG to heal gastric ulcers was evaluated after 14 consecutive days of treatment. The results showed that single oral administrations of AG (250 mg/kg/once daily) potently stimulates gastric epithelial cell proliferation that contributes to the accelerated healing of gastric ulcers induced by acetic acid. In addition, no subacute toxicity (body weight gain, vital organs, and serum biochemical parameters) was observed during treatment with AG. Phytochemical investigation of AG led to the isolation of myricetin-3-O-alpha-L-rhamnopyranoside, quercetin-3-O-alpha-L-arabinopyranoside, quercetin-3-O-beta-D-galactopyranoside, quercetin, amentoflavone, methyl gallate, gallic acid, and pterogynidine. We also established the phytochemical profile of AG with the quantification of total phenolic compounds. These compounds may contribute to the observed antiulcerogenic effects of AG.
dc.languageeng
dc.publisherPharmaceutical Soc Japan
dc.relationBiological & Pharmaceutical Bulletin
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlchornea glandulosa
dc.subjectproliferating cell nulear antigen (PCNA)
dc.subjectantiulcer activity
dc.subjectphenolic compound
dc.titleConstituents and antiulcer effect of Alchornea glandulosa: Activation of cell proliferation in gastric mucosa during the healing process
dc.typeOtro


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