Comparison of the cardio-respiratory effects of methadone and morphine in conscious dogs

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMaiante, A. A.
dc.creatorTeixeira Neto, Francisco José
dc.creatorBeier, S. L.
dc.creatorCorrente, J. E.
dc.creatorPedroso, C. E. B. P.
dc.date2014-05-20T13:39:16Z
dc.date2016-10-25T16:55:08Z
dc.date2014-05-20T13:39:16Z
dc.date2016-10-25T16:55:08Z
dc.date2009-08-01
dc.date.accessioned2017-04-05T20:36:57Z
dc.date.available2017-04-05T20:36:57Z
dc.identifierJournal of Veterinary Pharmacology and Therapeutics. Malden: Wiley-blackwell Publishing, Inc, v. 32, n. 4, p. 317-328, 2009.
dc.identifier0140-7783
dc.identifierhttp://hdl.handle.net/11449/13619
dc.identifierhttp://acervodigital.unesp.br/handle/11449/13619
dc.identifier10.1111/j.1365-2885.2008.01042.x
dc.identifierWOS:000267832700002
dc.identifier0000-0001-5478-4996
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2885.2008.01042.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/860904
dc.descriptionThe effects of methadone and morphine were compared in conscious dogs. Six animals received morphine sulfate (1 mg/kg) or methadone hydrochloride (0.5 mg/kg [MET0.5] or 1.0 mg/kg [MET1.0]) intravenously (i.v.) in a randomized complete block design. Cardiopulmonary variables were recorded before (baseline), and for 120 min after drug administration. One outlier was not included in the statistical analysis for hemodynamic data. Morphine decreased heart rate (HR) compared to baseline from 30 to 120 min (-15% to -26%), while cardiac index (CI) was reduced only at 120 min (-19%). Greater and more prolonged reductions in HR (-32% to -46%) and in CI (-24% to -52%) were observed after MET1.0, while intermediate reductions were recorded after MET0.5 (-19 to -28% for HR and -17% to -27% for CI). The systemic vascular resistance index (SVRI) was increased after methadone; MET1.0 produced higher SVRI values than MET0.5 (maximum increases: 57% and 165% for MET0.5 and MET1.0, respectively). Compared to morphine, oxygen partial pressure (PaO(2)) was lower (-12% to -13%) at 5 min of methadone (0.5 and 1.0 mg/kg), while carbon dioxide partial pressure (PaCO(2)) did not change significantly. It was concluded that methadone induces cardiovascular changes that are dose-related and is a more potent cardiovascular depressant agent than morphine in conscious dogs.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherWiley-Blackwell Publishing, Inc
dc.relationJournal of Veterinary Pharmacology and Therapeutics
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleComparison of the cardio-respiratory effects of methadone and morphine in conscious dogs
dc.typeOtro


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