Effect of the bacillus of Calmette-Guerin, Propionibacterium acnes and avridine as immunomodulators in antirabies vaccination of mice using the Fuenzalida-Palacios mouse brain vaccine

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMegid, Jane
dc.creatorPeracolli, MTS
dc.creatorCuri, P. R.
dc.creatorZanetti, C. R.
dc.creatorCabrera, M. H.
dc.creatorVassao, R.
dc.creatorIto, F. H.
dc.date2014-05-20T13:38:11Z
dc.date2016-10-25T16:54:31Z
dc.date2014-05-20T13:38:11Z
dc.date2016-10-25T16:54:31Z
dc.date1999-05-14
dc.date.accessioned2017-04-05T20:34:51Z
dc.date.available2017-04-05T20:34:51Z
dc.identifierVaccine. Oxford: Elsevier B.V., v. 17, n. 19, p. 2446-2452, 1999.
dc.identifier0264-410X
dc.identifierhttp://hdl.handle.net/11449/13248
dc.identifierhttp://acervodigital.unesp.br/handle/11449/13248
dc.identifier10.1016/S0264-410X(98)00465-4
dc.identifierWOS:000080800900015
dc.identifierhttp://dx.doi.org/10.1016/S0264-410X(98)00465-4
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/860630
dc.descriptionUsing the laboratory mice, Fuenzalida-Palacios mouse brain human rabies vaccine was administered in groups of animals previously inoculated with rabies virus and then submitted to treatments with the immunomodulators onco-BCG, avridine and Plopionibacterium acnes. Humoral and cellular immune responses were evaluated through the macrophage inhibition factor (MIF), intra-pad inoculation (IPI) and serum neutralization (SN) tests and by the detection of gamma-interferon (IFN-gamma). The IPI test was not effective in detecting the response of delayed-type hypersensitivity, contrary to MIF, which showed the immune cellular response. Higher levels of IFN-gamma were observed in the groups of mice vaccinated and treated with avridine and P. acnes. Although immunomodulating activities have been detected, the use of adjuvants with the Fuenzalida-Palacios type vaccine in mice did not reveal any encouraging results. (C) 1999 Elsevier B.V. Ltd. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationVaccine
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectrabies
dc.subjectvaccination
dc.subjectimmunomodulators
dc.subjectmice
dc.subjectimmunity
dc.titleEffect of the bacillus of Calmette-Guerin, Propionibacterium acnes and avridine as immunomodulators in antirabies vaccination of mice using the Fuenzalida-Palacios mouse brain vaccine
dc.typeOtro


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