POLYETHYLENE GLYCOL ADDITION DOES NOT IMPROVE EXOGENOUS SURFACTANT FUNCTION IN AN EXPERIMENTAL MODEL of MECONIUM ASPIRATION SYNDROME

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorLyra, João César
dc.creatorMascaretti, Renata Suman
dc.creatorPrecioso, Alexander Roberto
dc.creatorHaddad, Luciana Branco
dc.creatorMauad, Thais
dc.creatorVaz, Flavio A. Costa
dc.creatorRebello, Celso Moura
dc.date2014-05-20T13:37:59Z
dc.date2016-10-25T16:54:24Z
dc.date2014-05-20T13:37:59Z
dc.date2016-10-25T16:54:24Z
dc.date2009-01-01
dc.date.accessioned2017-04-05T20:34:22Z
dc.date.available2017-04-05T20:34:22Z
dc.identifierExperimental Lung Research. Philadelphia: Taylor & Francis Inc, v. 35, n. 1, p. 76-88, 2009.
dc.identifier0190-2148
dc.identifierhttp://hdl.handle.net/11449/13170
dc.identifierhttp://acervodigital.unesp.br/handle/11449/13170
dc.identifier10.1080/01902140802415837
dc.identifierWOS:000263090000005
dc.identifierhttp://dx.doi.org/10.1080/01902140802415837
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/860570
dc.descriptionMeconium (MEC) is a potent inactivator of pulmonary surfactant. The authors studied the effects of polyethylene glycol addition to the exogenous surfactant over the lung mechanics and volumes. Human meconium was administrated to newborn rabbits. Animals were ventilated for 20 minutes and dynamic compliance, ventilatory pressure, and tidal volume were recorded. Animals were randomized into 3 study groups: MEC group (without surfactant therapy); S100 group (100 mg/kg surfactant); and PEG group (100 mg/kg porcine surfactant plus 5% PEG). After ventilation, a pulmonary pressure-volume curve was built. Histological analysis was carried out to calculate the mean alveolar size (Lm) and the distortion index (DI). Both groups treated with surfactant showed higher values of dynamic pulmonary compliance and lower ventilatory pressure, compared with the MEC group (P .05). S100 group had a larger maximum lung volume, V30, compared with the MEC group (P .05). Lm and DI values were smaller in the groups treated with surfactant than in the MEC group (P .05). No differences were observed between the S100 and PEG groups. Animals treated with surfactant showed significant improvement in pulmonary function as compared to nontreated animals. PEG added to exogenous surfactant did not improve lung mechanics or volumes.
dc.languageeng
dc.publisherTaylor & Francis Inc
dc.relationExperimental Lung Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectmeconium
dc.subjectnewborn
dc.subjectpulmonary surfactant
dc.titlePOLYETHYLENE GLYCOL ADDITION DOES NOT IMPROVE EXOGENOUS SURFACTANT FUNCTION IN AN EXPERIMENTAL MODEL of MECONIUM ASPIRATION SYNDROME
dc.typeOtro


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