Tomato oleoresin inhibits DNA damage but not diethylnitrosamine-induced rat hepatocarcinogenesis

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorScolastici, Clarissa
dc.creatorLopes, Gisele A. D.
dc.creatorBarbisan, Luis Fernando
dc.creatorSalvadori, Daisy Maria Favero
dc.date2014-05-20T13:37:24Z
dc.date2016-10-25T16:54:04Z
dc.date2014-05-20T13:37:24Z
dc.date2016-10-25T16:54:04Z
dc.date2008-06-01
dc.date.accessioned2017-04-05T20:33:11Z
dc.date.available2017-04-05T20:33:11Z
dc.identifierExperimental and Toxicologic Pathology. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 60, n. 1, p. 59-68, 2008.
dc.identifier0940-2993
dc.identifierhttp://hdl.handle.net/11449/12932
dc.identifierhttp://acervodigital.unesp.br/handle/11449/12932
dc.identifier10.1016/j.etp.2008.01.010
dc.identifierWOS:000257260200007
dc.identifierhttp://dx.doi.org/10.1016/j.etp.2008.01.010
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/860417
dc.descriptionVarious studies have shown that lycopene, a non-provitamin A carotenoid, exerts antioxidant, antimutagenic and anticarcinogenic activities in different in vitro and in vivo systems. However, the results concerning its chemopreventive potential on rat hepatocarcinogenesis are ambiguous. The aim of the present study was to investigate the antigenotoxic and anticarcinogenic effects of dietary tomato oleoresin adjusted to lycopene concentration at 30, 100 or 300ppm (administered 2 weeks before and during or 8 weeks after carcinogen exposure) on liver of male Wistar rats treated with a single intraperitoneal dose of 20 or 100 mg/kg of diethylnitrosamine (DEN), respectively. The level of DNA damage in liver cells and the development of putative preneoplastic single hepatocytes, minifoci and foci of altered hepatocytes (FHA) positive for glutathione S-transferase (GST-P) were used as endpoints. Significant reduction of DNA damage was detected when the highest lycopene concentration was administered before and during the DEN exposure (20 mg/kg). However, the results also showed that lycopene consumption did not reduce cell proliferation in normal hepatocytes or the growth of initiated hepatocytes into minifoci positive for GST-P during early regenerative response after 70% partial hepatectomy, or the number and area of GST-P positive FHA induced by DEN (100 mg/ kg) at the end of week 10. Taken together, the data suggest a chemopreventive effect of tomato oleoresin against DNA damage induced by DEN but no clear effectiveness in initiating or promoting phases of rat hepatocarcinogenesis. (c) 2008 Elsevier GmbH. All rights reserved.
dc.languageeng
dc.publisherElsevier Gmbh, Urban & Fischer Verlag
dc.relationExperimental and Toxicologic Pathology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectchemoprevention
dc.subjectdiethylnitrosamine
dc.subjectDNA damage
dc.subjectGST-P liver foci
dc.subjecthepatocarcinogenesis
dc.subjecttomato oleoresin
dc.subjectlycopene
dc.titleTomato oleoresin inhibits DNA damage but not diethylnitrosamine-induced rat hepatocarcinogenesis
dc.typeOtro


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