dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorde Oliveira, Erick Prado
dc.creatorBurini, Roberto Carlos
dc.date2014-05-20T13:37:17Z
dc.date2014-05-20T13:37:17Z
dc.date2012-04-04
dc.date.accessioned2017-04-05T20:33:00Z
dc.date.available2017-04-05T20:33:00Z
dc.identifierDiabetology & Metabolic Syndrome. London: Biomed Central Ltd., v. 4, p. 7, 2012.
dc.identifier1758-5996
dc.identifierhttp://hdl.handle.net/11449/12886
dc.identifier10.1186/1758-5996-4-12
dc.identifierWOS:000304677700001
dc.identifierWOS000304677700001.pdf
dc.identifierhttp://dx.doi.org/10.1186/1758-5996-4-12
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/860397
dc.descriptionHigh plasma uric acid (UA) is a precipitating factor for gout and renal calculi as well as a strong risk factor for Metabolic Syndrome and cardiovascular disease. The main causes for higher plasma UA are either lower excretion, higher synthesis or both. Higher waist circumference and the BMI are associated with higher insulin resistance and leptin production, and both reduce uric acid excretion. The synthesis of fatty acids (tryglicerides) in the liver is associated with the de novo synthesis of purine, accelerating UA production. The role played by diet on hyperuricemia has not yet been fully clarified, but high intake of fructose-rich industrialized food and high alcohol intake (particularly beer) seem to influence uricemia. It is not known whether UA would be a causal factor or an antioxidant protective response. Most authors do not consider the UA as a risk factor, but presenting antioxidant function. UA contributes to > 50% of the antioxidant capacity of the blood. There is still no consensus if UA is a protective or a risk factor, however, it seems that acute elevation is a protective factor, whereas chronic elevation a risk for disease.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherBiomed Central Ltd.
dc.relationDiabetology & Metabolic Syndrome
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectUric acid
dc.subjectDiet
dc.subjectProtection
dc.subjectRisk
dc.subjectMetabolic syndrome
dc.titleHigh plasma uric acid concentration: causes and consequences
dc.typeOtro


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