Antimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamide

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorDelmanto, R. D.
dc.creatorde Lima, PLA
dc.creatorSugui, M. M.
dc.creatorda Eira, A. F.
dc.creatorSalvadori, Daisy Maria Favero
dc.creatorSpeit, G.
dc.creatorRibeiro, L. R.
dc.date2014-05-20T13:37:03Z
dc.date2016-10-25T16:53:53Z
dc.date2014-05-20T13:37:03Z
dc.date2016-10-25T16:53:53Z
dc.date2001-09-20
dc.date.accessioned2017-04-05T20:32:29Z
dc.date.available2017-04-05T20:32:29Z
dc.identifierMutation Research-genetic Toxicology and Environmental Mutagenesis. Amsterdam: Elsevier B.V., v. 496, n. 1-2, p. 15-21, 2001.
dc.identifier1383-5718
dc.identifierhttp://hdl.handle.net/11449/12781
dc.identifierhttp://acervodigital.unesp.br/handle/11449/12781
dc.identifier10.1016/S1383-5718(01)00228-5
dc.identifierWOS:000170481900003
dc.identifierhttp://dx.doi.org/10.1016/S1383-5718(01)00228-5
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/860327
dc.descriptionAgaricus blazei Murrill extracts have previously been shown to have anticarcinogenic and antimutagenic proper-ties. These results suggest that antimutagenic activity, besides the modulation of the immune system, might be involved in the anticarcinogenic action of A. blazei. To investigate the possible antimutagenic effect of A. blazei in vivo, we evaluated its effect on clastogenicity induced by cyclophosphamide (CP) in mice, using the micronucleus test in bone marrow (MNPCE) and in peripheral blood (MNRET). Male Swiss mice were treated with CP (25 or 50 mg/kg i.p.) or with CP plus mushroom solution at three different temperatures: 4, 21, and 60 degreesC. Aqueous solution of a mixture from various lineages of the mushroom inhibited induction of micronuclei by CP in bone marrow and in peripheral blood of mice. In contrast to the mixture of lineages, a single isolated lineage did not lead to a reduction of CP-induced MN frequencies in either bone marrow or blood cells of mice. The results suggest that under certain circumstances these mushrooms exhibit antimutagenic activities that might contribute to an anticarcinogenic effect. (C) 2001 Elsevier B.V. B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationMutation Research: Genetic Toxicology and Environmental Mutagenesis
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantimutagenicity
dc.subjectAgaricus blazei Murrill
dc.subjectmicronucleus test
dc.subjectcyclophosphamide
dc.titleAntimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamide
dc.typeOtro


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