Opsoclonus-myoclonus syndrome associated with herpes simplex encephalitis

dc.creatorAfonso, C.O.M.
dc.creatorCampos, M.L.S.
dc.creatorMaia, Ferdinand Gilbert Saraiva da Silva
dc.creatorCampêlo, C.L.C.
dc.creatorCamilo, A.F.C.
dc.creatorCorreia, Carlos Eduardo Rocha
dc.creatorFernandes, José Veríssimo
dc.creatorFigueiredo, Marcelo Marinho de
dc.creatorSilva, R.A.
dc.date2023-05-29T17:23:27Z
dc.date2023-05-29T17:23:27Z
dc.date2015-10-15
dc.date.accessioned2023-09-04T12:37:05Z
dc.date.available2023-09-04T12:37:05Z
dc.identifierCORREIA, Carlos Eduardo Rocha; et al. Opsoclonus-myoclonus syndrome associated with herpes simplex encephalitis. Journal Of The Neurological Sciences, [S.l.], v. 357, p. 56, out. 2015. Elsevier BV. Disponível em: https://www.sciencedirect.com/science/article/pii/S0022510X15007169?via%3Dihub. Acesso em: 29 mio 2023. DOI: http://dx.doi.org/10.1016/j.jns.2015.08.220
dc.identifierhttps://repositorio.ufrn.br/handle/123456789/52559
dc.identifier10.1016/j.jns.2015.08.220.
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8601440
dc.descriptionBackground: Opsoclonus-myoclonus ataxia is a rare neurologic syn drome, often paraneoplastic in origin, but reported in association with various infections. Little is known about adult-onset opsoclonus myoclonus syndrome (OMS) outside of individual case reports Objective: Describe a case of herpes-simplex virus 1 encephalitis presenting as opsoclonus-myoclonus ataxia Patients and methods: A 35 year-old woman, with no known comorbidities, developed a headache with nausea and vomiting, without fever or nuchal rigidity. In the following 48-hours, she presented an altered mental status, opsoclonus and myoclonus and was admitted to hospital. Lumbar puncture: 40 cells (60% mononu clear), protein 140 mg/dL and a normal glucose. Gram stain and culture for bacteria and fungi were negative. A PCR for herpes simplex virus was positive. Brain MRI: normal. Chest, Abdomen and Pelvis CT: no signs of neoplasia. Results: The patient received intra-venous acyclovir for 21 days, with resolution of symptoms Conclusion: OMS is an uncommon presentation of infections of central nervous system. Its fame extends further to the fact that OMS can be a harbinger of occult malignancy. The Adult-onset presentation is rare. Paraneoplastic and parainfectious causes (particularly virus) are common; however, more often OMS in adults occurs after systemic infection. After this report, HSV1 infection should be considered in OMS cases. We described the first case of OMS secondary to Herpes-Simplex Virus 1 infection.
dc.formatapplication/pdf
dc.languagept_BR
dc.publisherJournal Of The Neurological Sciences
dc.subjectopsoclonus-myoclonus
dc.subjectencephalitis
dc.subjectparaneoplastic
dc.titleOpsoclonus-myoclonus syndrome associated with herpes simplex encephalitis
dc.typearticle


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