Primary Pulmonary Choriocarcinoma After Human Chorionic Gonadotropin Normalization Following Hydatidiform Mole A Report of Two Cases

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMaestá, Izildinha
dc.creatorLeite, Fabio Vicente
dc.creatorMichelin, Odair Carlito
dc.creatorRogatto, Silvia Regina
dc.date2014-05-20T13:35:16Z
dc.date2016-10-25T16:52:42Z
dc.date2014-05-20T13:35:16Z
dc.date2016-10-25T16:52:42Z
dc.date2010-07-01
dc.date.accessioned2017-04-05T20:28:12Z
dc.date.available2017-04-05T20:28:12Z
dc.identifierJournal of Reproductive Medicine. St Louis: Sci Printers & Publ Inc, v. 55, n. 7-8, p. 311-316, 2010.
dc.identifier0024-7758
dc.identifierhttp://hdl.handle.net/11449/12118
dc.identifierhttp://acervodigital.unesp.br/handle/11449/12118
dc.identifierWOS:000280968800008
dc.identifierhttp://www.reproductivemedicine.com/toc/auto_abstract.php?id=23770
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/859777
dc.descriptionBACKGROUND: Primary pulmonary choriocarcinoma (PPC) is rare and frequently leads to death.CASES: Two young patients presented with previous molar pregnancy and spontaneous serum human chorionic gonadotropin (hCG) normalization. Patient 1 was referred to our center after partial response to chemotherapy. Pulmonary lobectomy was performed, and hCG rapidly declined. During further chemotherapy, liver metastasis was detected by positron emission tomography. Right hepatectomy was performed, and hCG declined for 28 days, but increased again despite chemotherapy. This patient died from hepatic failure 3 years after diagnosis. Patient 2 presented with persistently high hCG, though the affected organ was not identified. Chemotherapy was unsuccessful. Patient reevaluation showed an isolated pulmonary mass. Pulmonary lobectomy was performed; 2 weeks later, hCG was normal and consolidation with 2 cycles of chemotherapy was administered. The patient has been in remission for 24 months. PPC was confirmed by histo pathology and immunohistochemistry in both cases. Gestational origin of the tumor was confirmed by molecular genetic analysis (polymorphic microsatellite markers).CONCLUSION: The possibility of choriocarcinoma cannot be overlooked in young women with an isolated pulmonary mass. Early diagnosis, prompt chemotherapy, and surgical resection in a specialized center improves the prognosis. (J Reprod Med 2010;55:311-316)
dc.languageeng
dc.publisherSci Printers & Publ Inc
dc.relationJournal of Reproductive Medicine
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectgenetic origin
dc.subjectprimary pulmonary choriocarcinoma
dc.subjectsalvage therapy
dc.titlePrimary Pulmonary Choriocarcinoma After Human Chorionic Gonadotropin Normalization Following Hydatidiform Mole A Report of Two Cases
dc.typeOtro


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