Association between CD31 expression and histopathologic features in stage IB squamous cell carcinoma of the cervix

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSilva-Filho, A. L.
dc.creatorTraiman, Paulo
dc.creatorTriginelli, S. A.
dc.creatorReis, F. M.
dc.creatorPedrosa, M. S.
dc.creatorMiranda, D.
dc.creatorAbreu, E. S.
dc.creatorMacarenco, R.
dc.creatorCunha-Melo, JR
dc.date2014-05-20T13:35:05Z
dc.date2016-10-25T16:52:34Z
dc.date2014-05-20T13:35:05Z
dc.date2016-10-25T16:52:34Z
dc.date2006-03-01
dc.date.accessioned2017-04-05T20:27:43Z
dc.date.available2017-04-05T20:27:43Z
dc.identifierInternational Journal of Gynecological Cancer. Oxford: Blackwell Publishing, v. 16, n. 2, p. 757-762, 2006.
dc.identifier1048-891X
dc.identifierhttp://hdl.handle.net/11449/12045
dc.identifierhttp://acervodigital.unesp.br/handle/11449/12045
dc.identifier10.1111/j.1525-1438.2006.00362.x
dc.identifierWOS:000236943200046
dc.identifierhttp://dx.doi.org/10.1111/j.1525-1438.2006.00362.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/859715
dc.descriptionThis study was undertaken to evaluate the association between the expression of CD31 in the tumor and the histopathologic findings in patients with carcinoma of the cervix. This study included prospectively 30 women, aged 46.6 +/- 10.7 years, with stage IB squamous cell carcinoma of the cervix submitted to radical hysterectomy from November 2001 to September 2002. Samples from the tumor were taken and immunohistochemically evaluated by a monoclonal antibody for CD31. Clinicopathologic characteristics such as stage, tumor size, grade of differentiation, lymphatic vascular space invasion (LVSI), parametrial involvement, and status of pelvic lymph nodes were also recorded. The clinical stage (FIGO) was IB1 in 22 patients (73.3%) and IB2 in 8 patients (26.7%). The expression of CD31 was significantly associated with tumor size and the presence of LVSI, but not with grade of differentiation and vaginal or parametrial involvement (P= 0.03, P= 0.032, P= 0.352, P= 0.208, and P= 0.242, respectively). on univariate analysis, the presence of pelvic lymph node metastasis was influenced by LVSI (P= 0.003) and CD31 expression (P= 0.032). However, on multivariate analysis, the presence of LVSI (P= 0.007) was the only independent predictor of pelvic lymph node metastasis. The CD31 expression in tumor is significantly associated with LVSI and tumor size in patients with early-stage squamous cell carcinoma of the cervix.
dc.languageeng
dc.publisherBlackwell Publishing
dc.relationInternational Journal of Gynecological Cancer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectangiogenesis
dc.subjectcarcinoma
dc.subjectCD31
dc.subjectcervix
dc.titleAssociation between CD31 expression and histopathologic features in stage IB squamous cell carcinoma of the cervix
dc.typeOtro


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