Systemic response induced by Scorpaena plumieri fish venom initiates acute lung injury in mice

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBoletini-Santos, Douglas
dc.creatorKomegae, Evilin Naname
dc.creatorFigueiredo, Suely G.
dc.creatorHaddad, Vidal
dc.creatorLopes-Ferreira, Monica
dc.creatorLima, Carla
dc.date2014-05-20T13:34:05Z
dc.date2016-10-25T16:51:56Z
dc.date2014-05-20T13:34:05Z
dc.date2016-10-25T16:51:56Z
dc.date2008-03-15
dc.date.accessioned2017-04-05T20:25:25Z
dc.date.available2017-04-05T20:25:25Z
dc.identifierToxicon. Oxford: Pergamon-Elsevier B.V. Ltd, v. 51, n. 4, p. 585-596, 2008.
dc.identifier0041-0101
dc.identifierhttp://hdl.handle.net/11449/11669
dc.identifierhttp://acervodigital.unesp.br/handle/11449/11669
dc.identifier10.1016/j.toxicon.2007.11.011
dc.identifierWOS:000255377300011
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2007.11.011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/859413
dc.descriptionScorpaena plumieri venomous fish inflicted severe injuries in humans characterized by systemic effects and cardiovascular abnormalities. Although cardiotoxic and hypotensive effects induced in rats by this venom have been studied, little is known about their effect on bronchial epithelial permeability and airway inflammation in mice. The primary goal of this study was to determine whether the intraplantar or intraperitoneal injection of S. plumieri venom results in systemic response, and whether this event initiates acute lung injure. We found that BALB/c mice developed neutrophilic infiltrates, areas of lung hemorrhage and alveolar macrophage activation within 24 h after injection with S. plumieri venom. These histopathological changes were associated with an early increase in BAL fluid protein and early induction of cytokines, chemokines and matrix metaloproteinases, followed by a later increase in BAL fluid neutrophils. These findings provide clear evidence that the injection of S. plumieri venom in footpad or peritoneal cavity of mice results in venom deposition in the airway and initiates a sustained inflammatory response in the lungs. (C) 2007 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relationToxicon
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectScorpaena plumieri venom
dc.subjectlung injury
dc.subjectinflammatory mediators
dc.subjectalveolar macrophages
dc.titleSystemic response induced by Scorpaena plumieri fish venom initiates acute lung injury in mice
dc.typeOtro


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