Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGaiolla, Paula Schmidt Azevedo
dc.creatorPolegato, Bertha Furlan
dc.creatorMinicucci, Marcos Ferreira
dc.creatorPio, Stephan M.
dc.creatorSilva, Igor A.
dc.creatorSantos, Priscila P.
dc.creatorOkoshi, Katashi
dc.creatorPaiva, Sergio Alberto Rupp de
dc.creatorZornoff, Leonardo Antonio Mamede
dc.date2014-05-20T13:33:21Z
dc.date2016-10-25T16:51:27Z
dc.date2014-05-20T13:33:21Z
dc.date2016-10-25T16:51:27Z
dc.date2012-07-01
dc.date.accessioned2017-04-05T20:23:40Z
dc.date.available2017-04-05T20:23:40Z
dc.identifierMedical Science Monitor. Smithtown: Int Scientific Literature, Inc, v. 18, n. 7, p. BR253-BR258, 2012.
dc.identifier1234-1010
dc.identifierhttp://hdl.handle.net/11449/11418
dc.identifierhttp://acervodigital.unesp.br/handle/11449/11418
dc.identifierWOS:000306883300004
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22739724
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/859188
dc.descriptionBackground: The objective of this study was to determine the early echocardiographic predictors of elevated left ventricular end-diastolic pressure (LVEDP) after a long follow-up period in the infarcted rat model.Material/Methods: Five days and three months after surgery, sham and infarcted animals were subjected to transthoracic echocardiography. Regression analysis and receiver-operating characteristic (ROC) curve were performed for predicting increased LVEDP 3 months after MI.Results: Among all of the variables, assessed 5 days after myocardial infarction, infarct size (OR: 0.760; CI 95% 0.563-0.900; p=0.005), end-systolic area (ESA) (OR: 0.761; Cl 95% 0.564-0.900; p=0.008), fractional area change (FAC) (OR: 0.771; CI 95% 0.574-0.907; p=0.003), and posterior wall-shortening velocity (PWSV) (OR: 0.703; CI 95% 0.502-0.860; p=0.048) were predictors of increased LVEDP. The LVEDP was 3.6 +/- 1.8 mmHg in the control group and 9.4 +/- 7.8 mmHg among the infarcted animals (p=0.007). Considering the critical value of predictor variables in inducing cardiac dysfunction, the cut-off value was 35% for infarct size, 0.33 cm(2) for ESA, 40% for FAC, and 26 mm/s for PWSV.Conclusions: Infarct size, FAC, ESA, and PWSV, assessed five days after myocardial infarction, can be used to estimate an increased LVEDP three months following the coronary occlusion.
dc.languageeng
dc.publisherInt Scientific Literature, Inc
dc.relationMedical Science Monitor
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectheart failure
dc.subjectcardiac function
dc.subjectremodeling
dc.titleEarly echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats
dc.typeOtro


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