Alterations in myocardial collagen content affect rat papillary muscle function

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMatsubara, Luiz Shiguero
dc.creatorMatsubara, Beatriz Bojikian
dc.creatorOkoshi, Marina Politi
dc.creatorCicogna, Antonio Carlos
dc.creatorJanicki, J. S.
dc.date2014-05-20T13:32:54Z
dc.date2016-10-25T16:51:09Z
dc.date2014-05-20T13:32:54Z
dc.date2016-10-25T16:51:09Z
dc.date2000-10-01
dc.date.accessioned2017-04-05T20:22:36Z
dc.date.available2017-04-05T20:22:36Z
dc.identifierAmerican Journal of Physiology-heart and Circulatory Physiology. Bethesda: Amer Physiological Soc, v. 279, n. 4, p. H1534-H1539, 2000.
dc.identifier0363-6135
dc.identifierhttp://hdl.handle.net/11449/11251
dc.identifierhttp://acervodigital.unesp.br/handle/11449/11251
dc.identifierWOS:000089547600012
dc.identifierhttp://ajpheart.physiology.org/content/279/4/H1534
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/859047
dc.descriptionWe investigated the influence of myocardial collagen volume fraction (CVF, %) and hydroxyproline concentration (mu g/mg) on rat papillary muscle function. Collagen excess was obtained in 10 rats with unilateral renal ischemia for 5 wk followed by 3-wk treatment with ramipril (20 mg . kg(-1) . day(-1)) (RHTR rats; CVF = 3.83 +/- 0.80, hydroxyproline = 3.79 +/- 0.50). Collagen degradation was induced by double infusion of oxidized glutathione (GSSG rats; CVF 5 2.45 +/- 0.52, hydroxyproline = 2.85 +/- 0.18). Nine untreated rats were used as controls (CFV = 3.04 +/- 0.58, hydroxyproline = 3.21 +/- 0.30). Active stiffness (AS; g . cm(-2) . %L-max(-1)) and myocyte cross-sectional area (MA; mu m(2)) were increased in the GSSG rats compared with controls [AS 5.86 vs. 3.96 (P< 0.05); MA 363 +/- 59 vs. 305 +/- 28 (P< 0.05)]. In GSSG and RHTR groups the passive tension-length curves were shifted downwards, indicating decreased passive stiffness, and upwards, indicating increased passive stiffness, respectively. Decreased collagen content induced by GSSG is related to myocyte hypertrophy, decreased passive stiffness, and increased AS, and increased collagen concentration causes myocardial diastolic dysfunction with no effect on systolic function.
dc.languageeng
dc.publisherAmer Physiological Soc
dc.relationAmerican Journal of Physiology-heart and Circulatory Physiology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectrenovascular hypertension
dc.subjectfibrosis
dc.subjectoxidized glutathione
dc.subjectactive stiffness
dc.subjectpassive stiffness
dc.titleAlterations in myocardial collagen content affect rat papillary muscle function
dc.typeOtro


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