Dysautonomia and ventricular dysfunction in the indeterminate form of Chagas disease

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMolina, Roberta B. G.
dc.creatorMatsubara, Beatriz Bojikian
dc.creatorHueb, João Carlos
dc.creatorZanati, Silmeia Garcia
dc.creatorMeira, Domingos A.
dc.creatorCassolato, Jose Luiz
dc.creatorPaiva, Sergio Alberto Rupp de
dc.creatorZornoff, Leonardo Antonio Mamede
dc.date2014-05-20T13:32:53Z
dc.date2016-10-25T16:51:07Z
dc.date2014-05-20T13:32:53Z
dc.date2016-10-25T16:51:07Z
dc.date2006-11-10
dc.date.accessioned2017-04-05T20:22:30Z
dc.date.available2017-04-05T20:22:30Z
dc.identifierInternational Journal of Cardiology. Clare: Elsevier B.V., v. 113, n. 2, p. 188-193, 2006.
dc.identifier0167-5273
dc.identifierhttp://hdl.handle.net/11449/11240
dc.identifierhttp://acervodigital.unesp.br/handle/11449/11240
dc.identifier10.1016/j.ijcard.2005.11.010
dc.identifierWOS:000242312500007
dc.identifierhttp://dx.doi.org/10.1016/j.ijcard.2005.11.010
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/859037
dc.descriptionBackground: the associations between autonomic function and biventricular function in patients with the indeterminate form of Chagas disease remains to be elucidated.Methods: In 42 asymptornatic patients and 19 healthy volunteers, the autonomic function was assessed by time domain indices of heart rate variability (HRV), analyzed for 24 h; the right ventricular function was assessed by fraction area change, right ventricle shortening, and systolic excursion of the tricuspid valve; and the left ventricular function was assessed by ejection fraction and transmittal flow velocities. Data were expressed as mean SD or medians (including the lower quartile and upper quartile). Groups were compared by Student's t or Mann-Whitney U test. Autonomic and ventricular function were correlated by Pearson's or Spearman's correlation coefficient. The level of significance was 5%.Results: Right and left ventricular systolic function indexes were comparable between groups. Transmittal flow velocities were decreased in the Chagas disease group (p < 0.05). The patients presented impaired HRV as indicated by the values of SDNN-day (80 (64-99) ms vs. 98 (78-127) ms; p = 0.045), SDNNI-24 It (54 (43-71) vs. 65 (54-105) ms; p = 0.027), SDNNI-day (49 (42-64) vs. 67 (48-76) ms; p = 0.045), pNN50-day (2.2 (0.7-5)% vs. 10 (3-11)%; p = 0.033); and pNN50-24 It (3 (1-7)% vs. 12 (8-19)%; p = 0.013). There were no correlations between the left ventricular diastolic indices and autonomic dysfunctional indices (p > 0.05).Conclusion: Patients with the indeterminate form of Chagas disease have both dysautonomia, and left ventricular diastolic dysfunction. However, the right ventricular function is preserved. Importantly, ventricular diastolic dysfunction and dysautonomia. are independent phenomena. (c) 2005 Elsevier B.V.. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationInternational Journal of Cardiology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectdiastolic dysfunction
dc.subjectright ventricular function
dc.subjectautonomic control
dc.titleDysautonomia and ventricular dysfunction in the indeterminate form of Chagas disease
dc.typeOtro


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