Thyroid cell proliferation in Graves' disease - Use of MIB-1 monoclonal antibody

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMazeto, GMFS
dc.creatorOliveira, MLCS
dc.creatorPadovani, Carlos Roberto
dc.creatorMontenegro, MRG
dc.creatorAragon, F. E.
dc.creatorSchmitt, FCL
dc.date2014-05-20T13:32:52Z
dc.date2016-10-25T16:51:06Z
dc.date2014-05-20T13:32:52Z
dc.date2016-10-25T16:51:06Z
dc.date2004-01-01
dc.date.accessioned2017-04-05T20:22:26Z
dc.date.available2017-04-05T20:22:26Z
dc.identifierActa Cytologica. St Louis: Sci Printers & Publ Inc., v. 48, n. 1, p. 57-63, 2004.
dc.identifier0001-5547
dc.identifierhttp://hdl.handle.net/11449/11232
dc.identifierhttp://acervodigital.unesp.br/handle/11449/11232
dc.identifier10.1159/000326284
dc.identifierWOS:000188470800011
dc.identifierhttp://dx.doi.org/10.1159/000326284
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/859030
dc.descriptionOBJECTIVE: To measure thyroid cell proliferation in patients with Graves' disease (GD) before and during treatment with antithyroid drugs.STUDY DESIGN: Patients were assessed by fine needle aspiration biopsy before (n=20) and after 4 (n=19) and 12 months of treatment (n=15) with propylthiouracil or methimazole. Cell proliferation index (CPI) was estimated by immunocytochemistry using MIB-1. CPI was studied in relation to the cytologic parameters of the smears; clinical parameters, such as Wayne's Clinical Index (WCI) and time without treatment; laboratory parameters, such as (131)Iuptake and dosage of serum free thyroxin and thyroid-stimulating hormone; and thyroid ultrasound.RESULTS: CPI varied from 0.00% to 25.00% before treatment, 0.00% to 23.00% at 4 months and 0.00% to 14.84% at 12 months. CPI median values were 6.50%, 4.30% and 3.30%, respectively (before and after 4 months and 12 months of treatment). CPI had a positive correlation with WCI and FT4 at 12 months of treatment.CONCLUSION: Thyroid CPI in GD varies from case to case. However, due to its decreasing pattern during follow-up and its positive correlation with thyrotoxicosis severity, CPI may indicate the functional status of the gland and contribute to a better understanding of GD.
dc.languageeng
dc.publisherSci Printers & Publ Inc
dc.relationActa Cytologica
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGraves' disease
dc.subjectthyroid diseases
dc.subjectaspiration biopsy
dc.subjectmonoclonal antibodies
dc.subjectMIB-1
dc.titleThyroid cell proliferation in Graves' disease - Use of MIB-1 monoclonal antibody
dc.typeOtro


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