Effects of Compounds from Passiflora edulis Sims f. flavicarpa Juice on Blood Coagulation and on Proteolytic Enzymes

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSato, Ana Claudia
dc.creatorAndrade, Sonia A.
dc.creatorBrito, Marlon V.
dc.creatorMiranda, Antonio
dc.creatorSampaio, Misako Uemura
dc.creatorMaffei, Francisco Humberto de Abreu
dc.creatorVilela Oliva, Maria Luiza
dc.date2014-05-20T13:32:39Z
dc.date2016-10-25T16:50:56Z
dc.date2014-05-20T13:32:39Z
dc.date2016-10-25T16:50:56Z
dc.date2012-05-01
dc.date.accessioned2017-04-05T20:21:49Z
dc.date.available2017-04-05T20:21:49Z
dc.identifierProtein and Peptide Letters. Sharjah: Bentham Science Publ Ltd, v. 19, n. 5, p. 501-508, 2012.
dc.identifier0929-8665
dc.identifierhttp://hdl.handle.net/11449/11141
dc.identifierhttp://acervodigital.unesp.br/handle/11449/11141
dc.identifierWOS:000303311100004
dc.identifierhttp://eurekaselect.com/96614/article
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/858949
dc.descriptionPassion fruit (Passiflora edulis Sims f. flavicarpa) is popularly known for its sedative and calming properties and is consumed as a fresh fruit or as a juice. The clinical observation of blood incoagulability associated with excessive consumption of passion fruit juice, in a patient treated with warfarin, prompted the current study to investigate in vitro the presence of blood clotting inhibitors in Passiflora edulis Sims f. flavicarpa extract. After purification process, two compounds of distinct molecular weight and inhibitory action were better characterized. One is a trypsin inhibitor similar to inhibitors from Bowman-Birk family, named PeTI-I12, and other is a compound active in coagulation that prolongs aPTT and PT, but does not change TT. The aim of this study is to provide evidence that passion fruit extract's components play a role on hemostasis and therefore may be relevant in the handling of patients treated with anticoagulants or suffering hemorrhagic diseases.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherBentham Science Publ Ltd
dc.relationProtein and Peptide Letters
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectaPTT
dc.subjectblood coagulation
dc.subjectBowman-Birk inhibitor
dc.subjectPassiflora edulis
dc.subjectpassion fruit
dc.subjectPassifloraceae
dc.subjecttrypsin inhibitor
dc.subjectwarfarin
dc.titleEffects of Compounds from Passiflora edulis Sims f. flavicarpa Juice on Blood Coagulation and on Proteolytic Enzymes
dc.typeOtro


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