Spontaneous canine transmissible venereal tumor: cell morphology and influence on P-glycoprotein expression

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorJantzen Gaspar, Luis Fernando
dc.creatorFerreira, Isabelle
dc.creatorColodel, Marcia Moleta
dc.creatorSeullner Brandao, Claudia Valeria
dc.creatorRocha, Noeme Sousa
dc.date2014-05-20T13:32:35Z
dc.date2014-05-20T13:32:35Z
dc.date2010-01-01
dc.date.accessioned2017-04-05T20:21:36Z
dc.date.available2017-04-05T20:21:36Z
dc.identifierTurkish Journal of Veterinary & Animal Sciences. Ankara: Scientific Technical Research Council Turkey-tubitak, v. 34, n. 5, p. 447-454, 2010.
dc.identifier1300-0128
dc.identifierhttp://hdl.handle.net/11449/11112
dc.identifier10.3906/vet-0911-198
dc.identifierWOS:000285649400005
dc.identifierWOS000285649400005.pdf
dc.identifierhttp://dx.doi.org/10.3906/vet-0911-198
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/858923
dc.descriptionThe present study aimed to determine P-glycoprotein expression according to TVT cell morphology in 42 dogs with confirmed TVT, classified into lymphocytoid, plasmocytoid, and mixed. The chemotherapy efficiency was investigated along with its relation to P-glycoprotein expression in tumoral cells, evaluated by immunocytochemistry, considering positive tumors more than 10% stained. Among the samples collected, 50.00% possessed plasmocytoid morphology, 18.63% lymphocytoid, and 31.37% mixed. The plasmocytoid presented greater immunoreactivity to the anti-P-glycoprotein antibody in relation to the lymphocytoid. It was observed that the plasmocytoid was less sensitive to chemotherapy. The cases that had partial clinical response in the lymphocytoid were less compared with those in the plasmocytoid. Therefore, we can infer that the plasmocytoid presents a potential drug resistance. Based on this study, it can be concluded that the plasmocytoid presents a higher frequency of partial clinical response than the lymphocytoid and mixed, possibly through its higher percentage of anti-P-glycoprotein antibody expression.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherScientific Technical Research Council Turkey-tubitak
dc.relationTurkish Journal of Veterinary & Animal Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDog
dc.subjectTVT
dc.subjectP-glycoprotein
dc.subjectcell morphology
dc.titleSpontaneous canine transmissible venereal tumor: cell morphology and influence on P-glycoprotein expression
dc.typeOtro


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