Comparison of lung tissue concentrations of nebulized ceftazidime in ventilated piglets: ultrasonic versus vibrating plate nebulizers

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFerrari, Fabio
dc.creatorLiu, Zhi-Hai
dc.creatorLu, Qin
dc.creatorBecquemin, Marie-Helene
dc.creatorLouchahi, Kamel
dc.creatorAymard, Guy
dc.creatorMarquette, Charles-Hugo
dc.creatorRouby, Jean-Jacques
dc.date2014-05-20T13:32:02Z
dc.date2016-10-25T16:50:30Z
dc.date2014-05-20T13:32:02Z
dc.date2016-10-25T16:50:30Z
dc.date2008-09-01
dc.date.accessioned2017-04-05T20:20:17Z
dc.date.available2017-04-05T20:20:17Z
dc.identifierIntensive Care Medicine. New York: Springer, v. 34, n. 9, p. 1718-1723, 2008.
dc.identifier0342-4642
dc.identifierhttp://hdl.handle.net/11449/10928
dc.identifierhttp://acervodigital.unesp.br/handle/11449/10928
dc.identifier10.1007/s00134-008-1126-4
dc.identifierWOS:000258562800026
dc.identifierhttp://dx.doi.org/10.1007/s00134-008-1126-4
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/858753
dc.descriptionObjective: To compare the efficiency of an Aeroneb Pro vibrating plate and an Atomisor MegaHertz ultrasonic nebulizer for providing ceftazidime distal lung deposition.Design: In vitro experiments. One gram of cetazidime was nebulized in respiratory circuits and mass median aerodynamic diameter of particles generated by ultrasonic and vibrating plate nebulizers was compared using a laser velocimeter. In vivo experiments. Lung tissue concentrations and extrapulmonary depositions were measured in ten anesthetized ventilated piglets with healthy lungs that received 1 g of ceftazidime by nebulization with either an ultrasonic (n = 5), or a vibrating plate (n = 5) nebulizer.Setting: A two-bed Experimental Intensive Care Unit of a University School of Medicine.Intervention: Following sacrifice, 5 subpleural specimens were sampled in dependent and nondependent lung regions for measuring ceftazidime lung tissue concentrations by high-performance liquid chromatography.Measurements and results: Mass median aerodynamic diameters generated by both nebulizers were similar with more than 95% of the particles between 0.5 and 5 mu m. Lung tissue concentrations were 553 +/- 123 [95% confidence interval: 514-638] mu g g(-1) using ultrasonic nebulizer, and 452 +/- 172 [95% confidence interval: 376-528] mu g g(-1) using vibrating plate nebulizers (NS). Extrapulmonary depositions were, respectively, of 38 +/- 5% (ultrasonic) and 34 +/- 4% (vibrating plate) (NS).Conclusions: Vibrating plate nebulizer is comparable to ultrasonic nebulizers for ceftazidime nebulization. It may represent a new attractive technology for inhaled antibiotic therapy.
dc.languageeng
dc.publisherSpringer
dc.relationIntensive Care Medicine
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectultrasonic
dc.subjectvibrating plate
dc.subjectnebulizer
dc.subjectnebulization of antibiotics
dc.subjectlung tissue concentration
dc.titleComparison of lung tissue concentrations of nebulized ceftazidime in ventilated piglets: ultrasonic versus vibrating plate nebulizers
dc.typeOtro


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