Effect of a nanostructured dendrimer-naloxonazine complex on endogenous opioid peptides mu(1) receptor-mediated post-ictal antinociception

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFelippotti, Tatiana Tocchini
dc.creatordo Carmo, Devaney Ribeiro
dc.creatorPaim, Leonardo Lataro
dc.creatorStradiotto, Nelson Ramos
dc.creatorBicalho, Urquisa de Oliveira
dc.creatorParada, Carlos Amilcar
dc.creatorGrillo, Renato
dc.creatorFraceto, Leonardo Fernandes
dc.creatorCoimbra, Norberto Cysne
dc.date2014-05-20T13:29:43Z
dc.date2016-10-25T16:48:58Z
dc.date2014-05-20T13:29:43Z
dc.date2016-10-25T16:48:58Z
dc.date2011-12-01
dc.date.accessioned2017-04-05T20:14:41Z
dc.date.available2017-04-05T20:14:41Z
dc.identifierNanomedicine-nanotechnology Biology and Medicine. Amsterdam: Elsevier B.V., v. 7, n. 6, p. 871-880, 2011.
dc.identifier1549-9634
dc.identifierhttp://hdl.handle.net/11449/10046
dc.identifierhttp://acervodigital.unesp.br/handle/11449/10046
dc.identifier10.1016/j.nano.2011.02.005
dc.identifierWOS:000297699900023
dc.identifierhttp://dx.doi.org/10.1016/j.nano.2011.02.005
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/858036
dc.descriptionThe aim of this study was to investigate the capacity of the host dendrimer DAB-Am-16 as a drug carrier to reduce the time required for the encapsulated naloxonaxine to establish an irreversible covalent bond with mu(1)-opioid receptor (resulting in a pharmacologically selective effect). The efficacy of dendrimer-naloxonazine nanocomplex (DNC) was studied in antinociception induced by convulsions elicited by intraperitoneal (IP) administration of pentylenetetrazole, and analgesia was measured by the tail-flick test. We found that animals showed increased tail-flick latencies following convulsions. Furthermore, acute pre-treatment (10 minutes) with DNC, but not with naloxonazine alone, antagonized post-ictal analgesia in comparison with control pre-treatment. However, naloxonazine treatment 24 hours before PTZ decreased post-ictal antinociception, but DNC failed to antagonize tonic-clonic seizure-induced analgesia. In addition, according to Racine's index of seizure severity, naloxonazine, DAB-Am-16 dendrimer or DNC did not influence seizure severity when administered either 10 minutes or 24 hours before PTZ.From the Clinical Editor: This study characterizes the effect of a dendrimer-naloxonazine complex on mu(1) receptor-mediated post-ictal antinociception in an animal model of seizure disorder. (C) 2011 Elsevier B.V. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationNanomedicine-nanotechnology Biology and Medicine
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDAB-Am-16 Dendrimer
dc.subjectGABA-A receptor
dc.subjectmu(1)-opioid receptor
dc.subjectPost-ictal analgesia
dc.subjectnanostructured materials
dc.titleEffect of a nanostructured dendrimer-naloxonazine complex on endogenous opioid peptides mu(1) receptor-mediated post-ictal antinociception
dc.typeOtro


Este ítem pertenece a la siguiente institución