Natural rubber latex used as drug delivery system in guided bone regeneration (GBR)

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorHerculano, Rondinelli Donizetti
dc.creatorSilva, Cecília Pereira
dc.creatorEreno, Cibele
dc.creatorGuimaraes, Sérgio Augusto Catanzaro
dc.creatorKinoshita, Angela
dc.creatorGraeff, Carlos Frederico de Oliveira
dc.date2014-05-20T13:26:11Z
dc.date2014-05-20T13:26:11Z
dc.date2009-06-01
dc.date.accessioned2017-04-05T20:04:48Z
dc.date.available2017-04-05T20:04:48Z
dc.identifierMaterials Research. ABM, ABC, ABPol, v. 12, n. 2, p. 253-256, 2009.
dc.identifier1516-1439
dc.identifierhttp://hdl.handle.net/11449/8404
dc.identifier10.1590/S1516-14392009000200023
dc.identifierS1516-14392009000200023
dc.identifierWOS:000268332700023
dc.identifierS1516-14392009000200023.pdf
dc.identifierhttp://dx.doi.org/10.1590/S1516-14392009000200023
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856774
dc.descriptionIn this work, we propose natural rubber latex (NRL) membranes as a protein delivery system. For this purpose Bovine Serum Albumin (BSA) was incorporated into the latex solution for in vitro protein delivery experiments. Different polymerization temperatures were used, from -10 to 27 °C, in order to control the membrane morphology. These membranes were characterized by Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), as well as the Lowry Method to measure the BSA release. SEM and AFM microscopy analysis showed that the number, size and distribution of pores in NRL membranes can be varied, as well as its overall morphology. We have found that the morphology of the membrane is the predominant factor for higher protein release, compared with pore size and number of pores. Results demonstrated that the best drug-delivery system was the membrane polymerized at RT (27 °C), which does release 66% of its BSA content for up to 18 days. Our results indicate that NRLb could be used in the future as an active membrane that could accelerate bone healing in GBR.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherABM, ABC, ABPol
dc.relationMaterials Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectartificial membrane
dc.subjectbone regeneration
dc.subjectbiomaterials
dc.subjectguided bone regeneration
dc.subjectlatex
dc.titleNatural rubber latex used as drug delivery system in guided bone regeneration (GBR)
dc.typeOtro


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