Influence of the single or combined administration of cocaine and testosterone in autonomic and neuroendocrine responses to acute restraint stress

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCruz, Fabio C.
dc.creatorEngi, Sheila A.
dc.creatorLeao, Rodrigo M.
dc.creatorPlaneta, Cleopatra da Silva
dc.creatorCrestani, Carlos Cesar
dc.date2014-05-20T13:25:32Z
dc.date2016-10-25T16:45:58Z
dc.date2014-05-20T13:25:32Z
dc.date2016-10-25T16:45:58Z
dc.date2012-10-01
dc.date.accessioned2017-04-05T20:03:17Z
dc.date.available2017-04-05T20:03:17Z
dc.identifierJournal of Psychopharmacology. London: Sage Publications Ltd, v. 26, n. 10, p. 1366-1374, 2012.
dc.identifier0269-8811
dc.identifierhttp://hdl.handle.net/11449/8097
dc.identifierhttp://acervodigital.unesp.br/handle/11449/8097
dc.identifier10.1177/0269881112453210
dc.identifierWOS:000308578300008
dc.identifierhttp://dx.doi.org/10.1177/0269881112453210
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856572
dc.descriptionAbuse of cocaine and androgenic-anabolic steroids (AASs) has become a serious public health problem. Despite reports of an increase in the incidence of simultaneous abuse of these substances, potential toxic interactions between cocaine and AASs are poorly known. In the present study, we investigated the effects of either single or combined administration of testosterone and cocaine for one or 10 consecutive days on autonomic (arterial pressure, heart rate and tail cutaneous temperature) and neuroendocrine (plasma corticosterone) responses induced by acute restraint stress in rats. Combined administration of testosterone and cocaine for 10 days reduced the increase in heart rate and plasma corticosterone level, as well as the fall in tail skin temperature induced by restraint stress. Furthermore, repeated administration of cocaine inhibited the increase in arterial pressure observed during restraint, and this effect was not affected by coadministration of testosterone. Ten-day combined administration of testosterone and cocaine increased basal values of arterial pressure. Moreover, chronic administration of testosterone induced rest bradycardia and elevated basal level of plasma corticosterone. One-day single or combined administration of the drugs did not affect any parameter investigated. In conclusion, the present study demonstrated that combined administration of testosterone and cocaine changed the autonomic and neuroendocrine responses to acute restraint stress. These findings suggest that interaction between AASs and cocaine may affect the ability to cope with stressful events.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherSage Publications Ltd
dc.relationJournal of Psychopharmacology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAbuse
dc.subjectanabolic steroids
dc.subjectandrogens
dc.subjectcocaine
dc.subjectinteraction
dc.subjectstress
dc.subjectcardiovascular
dc.subjectHPA axis
dc.subjectglucocorticoids
dc.titleInfluence of the single or combined administration of cocaine and testosterone in autonomic and neuroendocrine responses to acute restraint stress
dc.typeOtro


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