Involvement of dopamine receptors in diethylpropion-induced conditioning place preference

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPlaneta, Cleopatra da Silva
dc.creatorDeLucia, R.
dc.date2014-05-20T13:25:31Z
dc.date2014-05-20T13:25:31Z
dc.date1998-04-01
dc.date.accessioned2017-04-05T20:03:15Z
dc.date.available2017-04-05T20:03:15Z
dc.identifierBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 4, p. 561-564, 1998.
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/11449/8088
dc.identifier10.1590/S0100-879X1998000400014
dc.identifierS0100-879X1998000400014
dc.identifierS0100-879X1998000400014.pdf
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1998000400014
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856569
dc.descriptionDiethylpropion (DEP) is an amphetamine-like agent used as an anorectic drug. Abuse of DEP has been reported and some restrictions of its use have been recently imposed. The conditioning place preference (CPP) paradigm was used to evaluate the reinforcing properties of DEP in adult male Wistar rats. After initial preferences were determined, animals weighing 250-300 g (N = 7 per group) were conditioned with DEP (10, 15 or 20 mg/kg). Only the dose of 15 mg/kg produced a significant place preference (358 ± 39 vs 565 ± 48 s). Pretreatment with the D1 antagonist SCH 23390 (0.05 mg/kg, sc) 10 min before DEP (15 mg/kg, ip) blocked DEP-induced CPP (418 ± 37 vs 389 ± 31 s) while haloperidol (0.5 mg/kg, ip), a D2 antagonist, 15 min before DEP was ineffective in modifying place conditioning produced by DEP (385 ± 36 vs 536 ± 41 s). These results suggest that dopamine D1 receptors mediate the reinforcing effect of DEP
dc.languageeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectdiethylpropion
dc.subjectconditioning place preference
dc.subjectreinforcing effect
dc.subjectdopamine receptors
dc.titleInvolvement of dopamine receptors in diethylpropion-induced conditioning place preference
dc.typeOtro


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