Otro
Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
Registro en:
Química Nova. Sociedade Brasileira de Química, v. 32, n. 5, p. 1222-1226, 2009.
0100-4042
10.1590/S0100-40422009000500026
S0100-40422009000500026
WOS:000269124800026
S0100-40422009000500026.pdf
Autor
Pavan, Fernando Rogério
Leite, Clarice Queico Fujimura
Coelho, Roberta Gomes
Coutinho, Isabel Duarte
Honda, Neli Kika
Cardoso, Claudia Andréa Lima
Vilegas, Wagner
Leite, Sergio Roberto de Andrade
Sato, Daisy Nakamura
Resumen
The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)