| dc.contributor | Universidade Estadual Paulista (UNESP) | |
| dc.creator | Cury, Beatriz S. F. | |
| dc.creator | de Castro, Ana Doris | |
| dc.creator | Klein, Stanlei Ivair | |
| dc.creator | Evangelista, Raul Cesar | |
| dc.date | 2014-05-20T13:24:53Z | |
| dc.date | 2016-10-25T16:45:32Z | |
| dc.date | 2014-05-20T13:24:53Z | |
| dc.date | 2016-10-25T16:45:32Z | |
| dc.date | 2009-11-17 | |
| dc.date.accessioned | 2017-04-05T20:01:36Z | |
| dc.date.available | 2017-04-05T20:01:36Z | |
| dc.identifier | Carbohydrate Polymers. Oxford: Elsevier B.V., v. 78, n. 4, p. 789-793, 2009. | |
| dc.identifier | 0144-8617 | |
| dc.identifier | http://hdl.handle.net/11449/7838 | |
| dc.identifier | http://acervodigital.unesp.br/handle/11449/7838 | |
| dc.identifier | 10.1016/j.carbpol.2009.06.017 | |
| dc.identifier | WOS:000270624200021 | |
| dc.identifier | http://dx.doi.org/10.1016/j.carbpol.2009.06.017 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/856371 | |
| dc.description | The influence of structural characteristics of high amylose cross-linked at different degrees on the release of drugs with important molecular differences, namely sodium diclophenac (SD) and nicotinamide (NI), was assessed in vitro from non-compacted systems. The release profiles were related with classical kinetic mathematical models for better understanding of the release mechanism. An increase in polymer cross-linking degree resulted in longer release time for both drugs, although SD generally was released slower than NI. SD release from samples cross-linked at 2% of basis was driven mainly by Fickian diffusion, while from samples cross-linked at 4% of basis follows anomalous mechanism. Inversely, anomalous mechanism was responsible for NI release from 2% samples and Fickian diffusion from 4% samples. Results suggest that the performance of cross-linked high amylose as excipient for controlled drug release not only depends on cross-linking degree but also is highly influenced by structural characteristics of the drug. (C) 2009 Elsevier Ltd. All rights reserved. | |
| dc.language | eng | |
| dc.publisher | Elsevier B.V. | |
| dc.relation | Carbohydrate Polymers | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | High amylose | |
| dc.subject | Cross-linking | |
| dc.subject | Nicotinamide | |
| dc.subject | Sodium diclophenac | |
| dc.subject | Release mechanism | |
| dc.title | Influence of phosphated cross-linked high amylose on in vitro release of different drugs | |
| dc.type | Otro | |
