Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorChorilli, Marlus
dc.creatorPrestes, P. S.
dc.creatorRigon, R. B.
dc.creatorLeonardi, G. R.
dc.creatorChiavacci, Leila Aparecida
dc.creatorSarmento, V. H. V.
dc.creatorOliveira, Anselmo Gomes de
dc.creatorScarpa, M. V.
dc.date2014-05-20T13:24:51Z
dc.date2016-10-25T16:45:30Z
dc.date2014-05-20T13:24:51Z
dc.date2016-10-25T16:45:30Z
dc.date2011-07-01
dc.date.accessioned2017-04-05T20:01:28Z
dc.date.available2017-04-05T20:01:28Z
dc.identifierColloids and Surfaces B-biointerfaces. Amsterdam: Elsevier B.V., v. 85, n. 2, p. 182-188, 2011.
dc.identifier0927-7765
dc.identifierhttp://hdl.handle.net/11449/7816
dc.identifierhttp://acervodigital.unesp.br/handle/11449/7816
dc.identifier10.1016/j.colsurfb.2011.02.027
dc.identifierWOS:000290842000011
dc.identifierhttp://dx.doi.org/10.1016/j.colsurfb.2011.02.027
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856352
dc.descriptionCarrier systems for lipophilic drugs, such as the liquid crystalline systems (LCS) have been extensively studied to improve effect and selectivity. Retinyl palmitate (RP) is widely used in pharmaceutical and cosmetics products to improve the skin elasticity. The aim of this study was the development, characterization and the in vivo effectiveness of RP in non-ionic LCS structures. LCS containing polyether functional siloxane as oil phase, silicon glycol copolymer as surfactant and water in the ratio 30:10:60, with and without RP were studied. The results of the polarized light microscopy, small-angle X-ray scattering and rheology analysis indicated the presence of typical LCS structures with lamellar arrangement. Regardless of the presence of RP, the rheological studies showed the pseudo plastic behavior of the systems. However, highest hysteresis area was verified when comparing the system in the presence and in the absence of RP. Stability study SAXS monitored, carried out up to 30 days in various storage temperature conditions (25 +/- 2 degrees C, 37 +/- 2 degrees C and 5 +/- 2 degrees C) demonstrated the great structural stability of the LCS systems. The in vivo effectiveness analysis suggests that the RP-loaded LCS provided a significant reduction of the orbicular wrinkles in human volunteers (P = 0.048). (C) 2011 Elsevier B.V. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationColloids and Surfaces B: Biointerfaces
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLiquid crystalline systems
dc.subjectRetinyl palmitate
dc.subjectSAXS
dc.subjectRheological analysis
dc.subjectIn vivo effectiveness
dc.titleStructural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system
dc.typeOtro


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