Synthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorChin, Chung Man
dc.creatordos Santos, Jean Leandro
dc.creatorOliveira, Ednir Vizioli
dc.creatorBlau, Lorena
dc.creatorMenegon, Renato Farina
dc.creatorPeccinini, Rosangela Goncalves
dc.date2014-05-20T13:24:46Z
dc.date2014-05-20T13:24:46Z
dc.date2009-09-01
dc.date.accessioned2017-04-05T20:01:16Z
dc.date.available2017-04-05T20:01:16Z
dc.identifierMolecules. Basel: Molecular Diversity Preservation International-mdpi, v. 14, n. 9, p. 3187-3197, 2009.
dc.identifier1420-3049
dc.identifierhttp://hdl.handle.net/11449/7781
dc.identifier10.3390/molecules14093187
dc.identifierWOS:000270201900007
dc.identifierWOS000270201900007.pdf
dc.identifierhttp://dx.doi.org/10.3390/molecules14093187
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856327
dc.descriptionThe compound 1-(2,6-dichlorophenyl)indolin-2-one (1), planned as a pro-drug of diclofenac (2), was easily synthesized in 94% yield by an intramolecular reaction in the presence of coupling agent (i.e., EDC). Compound 1 showed anti-inflammatory and analgesic activity without gastro-ulcerogenic effects. The chemical and enzymatic hydrolysis profile of the lactam derivative 1 does not indicate conversion to diclofenac (2). This compound is a new non-ulcerogenic prototype for treatment of chronic inflammatory diseases.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherMolecular Diversity Preservation International-mdpi
dc.relationMolecules
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectindolinone
dc.subjectpro-drug
dc.subjectanti-inflammatory
dc.subjecthydrolysis
dc.subjectdiclofenac
dc.titleSynthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties
dc.typeOtro


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