dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSalgado, HRN
dc.creatorLopes, CCGO
dc.creatorLucchesi, MBB
dc.date2014-05-20T13:24:41Z
dc.date2016-10-25T16:45:24Z
dc.date2014-05-20T13:24:41Z
dc.date2016-10-25T16:45:24Z
dc.date2006-02-13
dc.date.accessioned2017-04-05T20:01:04Z
dc.date.available2017-04-05T20:01:04Z
dc.identifierJournal of Pharmaceutical and Biomedical Analysis. Oxford: Pergamon-Elsevier B.V., v. 40, n. 2, p. 443-446, 2006.
dc.identifier0731-7085
dc.identifierhttp://hdl.handle.net/11449/7735
dc.identifierhttp://acervodigital.unesp.br/handle/11449/7735
dc.identifier10.1016/j.jpba.2005.07.020
dc.identifierWOS:000235319100031
dc.identifierhttp://dx.doi.org/10.1016/j.jpba.2005.07.020
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856305
dc.descriptionA simple, sensitive and specific agar diffusion bioassay for the antibacterial gatifloxacin was developed using a strain of Bacillus subtilis ATCC 9372 as the test organism. Gatifloxacin could be measured in tablets and raw material at concentration ranging 4-16 mu g ml(-1). The calibration graph for gatifloxacin was linear from 4.0 to 16.0 mu g ml(-1). A prospective validation of the method demonstrated that the method was linear (r(2) = 0.9993), precise (R.S.D. = 1.14%) and accurate. The results confirmed its precision and did not differ significantly from others methods described in the literature. The validated method yielded good results in terms of the range, linearity, precision, accuracy, specificity and recovery. We concluded that the microbiological assay is satisfactory for in vitro quantification of the antibacterial activity of gatifloxacin. (c) 2005 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationJournal of Pharmaceutical and Biomedical Analysis
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectgatifloxacin
dc.subjectfluoroquinolones
dc.subjectmicrobiological assay
dc.subjectpharmaceutical analysis
dc.subjectquality control
dc.subjectcylinder plate method
dc.titleMicrobiological assay for gatifloxacin in pharmaceutical formulations
dc.typeOtro


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