| dc.contributor | Universidade Estadual Paulista (UNESP) | |
| dc.creator | Baldan, Helen M. | |
| dc.creator | De Rosa, Helene J. | |
| dc.creator | Brunetti, Iguatemy Lourenço | |
| dc.creator | Ximenes, Valdecir Farias | |
| dc.creator | Machado, Rosangela G. P. | |
| dc.date | 2014-05-20T13:24:37Z | |
| dc.date | 2016-10-25T16:45:20Z | |
| dc.date | 2014-05-20T13:24:37Z | |
| dc.date | 2016-10-25T16:45:20Z | |
| dc.date | 2007-11-01 | |
| dc.date.accessioned | 2017-04-05T20:00:49Z | |
| dc.date.available | 2017-04-05T20:00:49Z | |
| dc.identifier | Biopharmaceutics & Drug Disposition. Chichester: John Wiley & Sons Ltd, v. 28, n. 8, p. 409-413, 2007. | |
| dc.identifier | 0142-2782 | |
| dc.identifier | http://hdl.handle.net/11449/7692 | |
| dc.identifier | http://acervodigital.unesp.br/handle/11449/7692 | |
| dc.identifier | 10.1002/bdd.570 | |
| dc.identifier | WOS:000251955200001 | |
| dc.identifier | http://dx.doi.org/10.1002/bdd.570 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/856273 | |
| dc.description | Tuberculosis chemotherapy involves combination of the drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR) for a 6-month period. The present work investigated the influence of RMP and PYR on the pharmacokinetic parameters of INH when groups of rats were pre-treated for 21 days with INH alone or in combination with RMP and/or PYR, in the following amounts per kg body weight: INH 100 mg; INH 100 mg + RMP 100 mg; INH 100 mg + PYR 350 mg; INH 100 mg + PYR 350 mg + RMP 100 mg. It was found that the co-administration of PYR caused an increase in the INH distribution volume (V-d/F), half-life of elimination t(1)/2(beta)) and clearance (Cl-T/F), and a decrease in the area under curve 0 to 24 h (AUC). Co-administration of RMP caused an increase in the Cl-T/F and a decrease in the AUC. The combination INH + PYR + RMP caused an increase in the Cl-T/F and a decrease in the AUC. These significant pharmacokinetic interactions between the tuberculostatic drugs might be related to differences in the therapeutic and toxic effects. Copyright 0( 2007 John Wiley & Sons, Ltd. | |
| dc.language | eng | |
| dc.publisher | Wiley-Blackwell | |
| dc.relation | Biopharmaceutics & Drug Disposition | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | pharmacokinetics | |
| dc.subject | isoniazid | |
| dc.subject | pyrazinamide | |
| dc.subject | rifampicin | |
| dc.title | The effect of rifampicin and pyrazinamide on isoniazid pharmacokinetics in rats | |
| dc.type | Otro | |
