Anti-diabetic activity of Bauhinia forficata decoction in streptozotocin-diabetic rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPepato, Maria Teresa
dc.creatorKeller, E. H.
dc.creatorBaviera, Amanda Martins
dc.creatorKettelhut, I. C.
dc.creatorVendramini, Regina Célia
dc.creatorBrunetti, Iguatemy Lourenço
dc.date2014-05-20T13:24:32Z
dc.date2016-10-25T16:45:16Z
dc.date2014-05-20T13:24:32Z
dc.date2016-10-25T16:45:16Z
dc.date2002-07-01
dc.date.accessioned2017-04-05T20:00:33Z
dc.date.available2017-04-05T20:00:33Z
dc.identifierJournal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 81, n. 2, p. 191-197, 2002.
dc.identifier0378-8741
dc.identifierhttp://hdl.handle.net/11449/7642
dc.identifierhttp://acervodigital.unesp.br/handle/11449/7642
dc.identifier10.1016/S0378-8741(02)00075-2
dc.identifierWOS:000176715300006
dc.identifierhttp://dx.doi.org/10.1016/S0378-8741(02)00075-2
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856236
dc.descriptionThe effects of using Bauhinia forficata leaf decoction (150 g leaf/l water; 35.2+/-7.8 ml/100 g body weight mean daily dose) as a drinking-water substitute for about I month on streptozotocin-diabetes (STZ-diabetes) in male Wistar rats were investigated. The physico-metabolic parameters measured were: body weight, food and liquid intake, urinary volume, hepatic glycogen, serum triglycerides and cholesterol, plasma glucose, urinary glucose and urea, and the weight of epididymal and retroperitoneal adipose tissue and soleus and extensor digitorum longus muscles. The STZ-diabetic rats treated with decoction showed a significant reduction in serum and urinary glucose and urinary urea as compared to the STZ-diabetic control, no difference being seen between decoction-treated and -untreated non-diabetic rats. The other physico-metabolic factors showed no changes in treated STZ-diabetic rats. The improvement in carbohydrate metabolism seen in the rats treated with Bauhinia forficata decoction does not appear to be linked to the inhibition of glycogenolysis or the stimulation of glycogenesis nor does it appear to act in a way similar to insulin or the sulfonylureas, although it may act by the inhibition of neoglycogenesis in a manner similar to that of the biguanides. (C) 2002 Elsevier B.V. Ireland Ltd. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationJournal of Ethnopharmacology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectanti-diabetic activity
dc.subjectBauhinia forficata
dc.subjectanti-hyperglycemic effect
dc.subjectstreptozotocin-diabetic rats
dc.titleAnti-diabetic activity of Bauhinia forficata decoction in streptozotocin-diabetic rats
dc.typeOtro


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