Cissus sicyoides (princess vine) in the long-term treatment of streptozotocin-diabetic rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPepato, Maria Teresa
dc.creatorBaviera, Amanda Martins
dc.creatorVendramini, Regina Célia
dc.creatorda Silva Perez, MDP
dc.creatorKettelhut, I. D.
dc.date2014-05-20T13:24:26Z
dc.date2016-10-25T16:45:09Z
dc.date2014-05-20T13:24:26Z
dc.date2016-10-25T16:45:09Z
dc.date2003-02-01
dc.date.accessioned2017-04-05T20:00:09Z
dc.date.available2017-04-05T20:00:09Z
dc.identifierBiotechnology and Applied Biochemistry. London: Portland Press, v. 37, p. 15-20, 2003.
dc.identifier0885-4513
dc.identifierhttp://hdl.handle.net/11449/7580
dc.identifierhttp://acervodigital.unesp.br/handle/11449/7580
dc.identifier10.1042/BA20020065
dc.identifierWOS:000181189200003
dc.identifierhttp://dx.doi.org/10.1042/BA20020065
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856187
dc.descriptionLeaf decoctions of Cissus sicyoides (princess vine) are taken widely as a popular remedy for diabetes mellitus in Brazil, where its common name is 'vegetal insulin'. However, there have been practically no attempts so far to determine scientifically whether it has antidiabetic effects and we decided to administer leaf decoctions, over extended periods, to normal and streptozotocin-diabetic rats, and investigate the effects of this treatment on the physiological and metabolic parameters that are altered in diabetic animals. The experimental model adopted was shown to be appropriate by running a parallel treatment with insulin, which led to expected improvements in several abnormal parameter values. The decoction treatment significantly reduced the intake of both food and fluid and the volume of urine excreted, as well as the levels of blood glucose, urinary glucose and urinary urea, in comparison with controls. Lipid metabolism was not affected by the treatment; nor was the level of hepatic glycogen in diabetic animals, which indicated that the mechanism responsible for the improvement in carbohydrate metabolism, observed in animals treated with the decoction, could not involve inhibition of glycogenolysis and/or stimulation of glycogenesis. The fact that normal animals treated with C. sicyoides exhibited no changes in any of the measured parameters suggests that its mode of action in diabetic animals does not resemble those of sulphonylurea or insulin. It may, however, act in a similar way to biguanide, via inhibition of gluconeogenesis.
dc.languageeng
dc.publisherPortland Press
dc.relationApplied Biochemistry and Biotechnology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectanti-diabetic activity
dc.subjectanti-diabetic plant
dc.subjectgluconeogenesis
dc.subjectplasma glucose
dc.subjectvegetal insulin
dc.titleCissus sicyoides (princess vine) in the long-term treatment of streptozotocin-diabetic rats
dc.typeOtro


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