| dc.contributor | Universidade Estadual Paulista (UNESP) | |
| dc.creator | Mainardes, Rubiana Mara | |
| dc.creator | Chaud, Marco Vinicius | |
| dc.creator | Gremião, Maria Palmira Daflon | |
| dc.creator | Evangelista, Raul Cesar | |
| dc.date | 2014-05-20T13:24:26Z | |
| dc.date | 2016-10-25T16:45:08Z | |
| dc.date | 2014-05-20T13:24:26Z | |
| dc.date | 2016-10-25T16:45:08Z | |
| dc.date | 2006-09-01 | |
| dc.date.accessioned | 2017-04-05T20:00:05Z | |
| dc.date.available | 2017-04-05T20:00:05Z | |
| dc.identifier | Journal of Nanoscience and Nanotechnology. Stevenson Ranch: Amer Scientific Publishers, v. 6, n. 9-10, p. 3057-3061, 2006. | |
| dc.identifier | 1533-4880 | |
| dc.identifier | http://hdl.handle.net/11449/7569 | |
| dc.identifier | http://acervodigital.unesp.br/handle/11449/7569 | |
| dc.identifier | 10.1166/jnn.2006.487 | |
| dc.identifier | WOS:000240865900051 | |
| dc.identifier | http://dx.doi.org/10.1166/jnn.2006.487 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/856178 | |
| dc.description | Praziquantel has been shown to be highly effective against all known species of Schistosoma infecting humans. Spherical nanoparticles made of poly(D,L-lactide-co-glycolide) acid with controlled size were designed as drug carriers. Praziquantel, a hydrophobic drug, was entrapped into the polymeric nanoparticles with 30% (w/w) of theoretical loading. The nanoparticles size was approximately of 350 nm with 66% of encapsulation efficiency. The everted gut sac model shows to be efficient to evaluate the drug permeation through the intestinal membrane. The results show that free praziquantel presents 4-fold times more permeation than praziquantel-loaded PLGA nanoparticles and physical mixture. For this drug, in special, this result can be interesting, since the nanoparticulate system can behave as a drug reservoir and/or to have a more localized effect in intestinal membrane for a prolonged period of time, since great amounts of parasites can be usually found in the mesenteric veins. | |
| dc.language | eng | |
| dc.publisher | Amer Scientific Publishers | |
| dc.relation | Journal of Nanoscience and Nanotechnology | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | nanoparticles | |
| dc.subject | PLGA | |
| dc.subject | praziquantel | |
| dc.subject | intestinal absorption | |
| dc.title | Development of praziquantel-loaded PLGA nanoparticles and evaluation of intestinal permeation by the everted gut Sac model | |
| dc.type | Otro | |
