Studies on the encapsulation of diclofenac in small unilamellar liposomes of soya phosphatidylcholine

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorLopes, L. B.
dc.creatorScarpa, M. V.
dc.creatorSilva, GVJ
dc.creatorRodrigues, D. C.
dc.creatorSantilli, C. V.
dc.creatorOliveira, Anselmo Gomes de
dc.date2014-05-20T13:24:25Z
dc.date2016-10-25T16:45:07Z
dc.date2014-05-20T13:24:25Z
dc.date2016-10-25T16:45:07Z
dc.date2004-12-25
dc.date.accessioned2017-04-05T20:00:01Z
dc.date.available2017-04-05T20:00:01Z
dc.identifierColloids and Surfaces B-biointerfaces. Amsterdam: Elsevier B.V., v. 39, n. 4, p. 151-158, 2004.
dc.identifier0927-7765
dc.identifierhttp://hdl.handle.net/11449/7560
dc.identifierhttp://acervodigital.unesp.br/handle/11449/7560
dc.identifier10.1016/j.colsurfb.2004.09.004
dc.identifierWOS:000225875100001
dc.identifierhttp://dx.doi.org/10.1016/j.colsurfb.2004.09.004
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856170
dc.descriptionThe encapsulation of acid (AD) and sodium diclofenac (SD) in small unilamellar liposomes (SUV) as well as the interactions of the drug with the bilayer was studied. SUV was prepared by sonication from multilamellar liposomes containing soya phosphatidylcholine and diclofenac at various proportions. The size distribution obtained from dynamic light scattering showed that the incorporation of SD decreases significantly the size of the liposomes suggesting that the drug interacts with the bilayer of the liposomes. This size decrease is related with the phase transition of liposomes to mixed micelar solution. The encapsulation of the hydrophilic dye indocyanine green in the aqueous compartment of liposomes showed that the rate of captured dye decreases with SD concentration suggesting the transition of liposomes to mixed micelles. The P-31 NMR analysis indicates that SD interacts with the phosphate of phosphatidylcholine head groups. A schematic model for interaction of SD with phosphatidylcholine of the liposomes in which the diclofenac anion interacts with the ammonium group of the phospholipid and the dichloropheryl ring occupies a more internal site of bilayer near phosphate group was proposed. (C) 2004 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationColloids and Surfaces B: Biointerfaces
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectliposome
dc.subjectmixed micelles
dc.subjectphase transformation
dc.subjectlight scattering
dc.subjectP-31 NMR
dc.titleStudies on the encapsulation of diclofenac in small unilamellar liposomes of soya phosphatidylcholine
dc.typeOtro


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